2001
DOI: 10.1159/000052417
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Small Cell Carcinoma of the Urinary Bladder

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Cited by 113 publications
(34 citation statements)
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“…Neuroendocrine markers such as synaptophysin, chromogranin-A and NSE staining are typical for SCC. Usually, there is a positive reading for at least one of these markers [20] . Bladder SCC tends to rapidly metastasize and the most common sites are distant lymph nodes, the liver and bone.…”
Section: Discussionmentioning
confidence: 99%
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“…Neuroendocrine markers such as synaptophysin, chromogranin-A and NSE staining are typical for SCC. Usually, there is a positive reading for at least one of these markers [20] . Bladder SCC tends to rapidly metastasize and the most common sites are distant lymph nodes, the liver and bone.…”
Section: Discussionmentioning
confidence: 99%
“…Metastatic disease is usually treated with chemotherapy and the most common scheme is the combination of cisplatin and etoposide as first-line therapy. Second-line therapy, as in SCC of the lung, can be performed with topotecan [20] . Siefker-Radtke et al [22] observed 12 patients with metastatic SCCUB who were treated with chemotherapy only and recorded a complete response of 72% with a median overall survival of 13.3 months.…”
Section: Discussionmentioning
confidence: 99%
“…Several different tumour markers of neuroendocrine differentiation have been demonstrated in 30% to 100% of cases of SCCB, with variable results across studies. 23,[40][41][42] Neuron-specific enolase (NSE) (25-100%), chromogranin A (22-89%), synaptophysin (67-76%), CD57, CD56, and protein gene product 9.5 (PGP9.5) 14,23,40,41,43 are markers that are often focally or diffusely positive in tumours with neuroendocrine differentiation.…”
Section: Pathological Diagnosismentioning
confidence: 99%
“…49 Ultimately, the diagnosis can be made based on the morphology alone for most of the cases, even if neuroendocrine differentiation cannot be demonstrated. 23,40,41,50 Molecular abnormalities and biomarkers of SCC of the bladder In SCCB, Soriano and colleagues demonstrated positive immunostaining for p53 in 80% and for c-erbB2 in 50% of cases. 41 Other transmembrane tyrosine kinase receptors, c-kit (CD117) 23,51 and EGFR 23,52 have been shown to be positive in about 30% of cases of SCCB.…”
Section: Pathological Diagnosismentioning
confidence: 99%
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