Small Cell Lung Cancer and Cancer-Associated Retinopathy

Bidegain, C.; Rigalt, J.; Ribot, Emeline J.; Dorca, Joan; Vayreda, Jordi

doi:10.1016/s1579-2129(06)60405-9

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…CAR syndrome, one form of paraneoplastic syndrome triggered by an autoimmune mechanism, is a degenerative retinopathy that is characterized by the production of an autoantibody to a retinal photoreceptor protein in the retinal cone, recoverin; the leading malignant cause of CAR is SCLC. [7][8][9] Clinical manifestations of CAR syndrome are photosensitivity, ring scotomatous visual loss, and attenuated retinal arteriole caliber.…”

Section: Discussionmentioning

confidence: 99%

Choroidal metastasis in a patient with small cell lung cancer discovered during treatment with chemotherapy

et al. 2009

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A 56-year-old male patient complaining of productive cough, hoarseness, and fatigue was found to have extensive disease of small cell lung cancer (ED-SCLC), with staging of cT4N3M1(PUL). He was treated with chemotherapy. While undergoing treatment with chemotherapy, he complained of a right visual disturbance, and choroidal metastasis was diagnosed. Because the primary site responded well to chemotherapy alone and the visual disturbance did not worsen, the patient refused radiotherapy to the choroidal metastasis. Two months after the first diagnosis of the choroidal metastasis, while he was receiving the first treatment regimen for SCLC, the visual disturbance suddenly worsened; emergent radiotherapy was started, with a total dose of 40 Gy, given as 2.0 Gy/fraction per day. The visual disturbance never improved, and the patient lost 80% of his right visual field. Within 6 months of diagnosis, the patient became blind in his right eye. The patient died of septic shock related to treatment received during his third chemotherapy regimen. Choroidal metastasis is very rare with extraocular malignant tumors, though it is common with intraocular malignant tumors. Choroidal metastasis secondary to SCLC has a poor prognosis, but in order to maintain quality of life during the patients' remaining lifespan, aggressive treatment would appear appropriate for these patients, because SCLC is a chemo-sensitive cancer.

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Section: Discussionmentioning

confidence: 99%

Choroidal metastasis in a patient with small cell lung cancer discovered during treatment with chemotherapy

et al. 2009

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Rétinopathies paranéoplasiques

Cochard-Marianowski¹,

Benchekroun-Bettembourg²

2010

Les Uvéites

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Small cell lung cancer and progressive retinopathy

et al. 2014

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Cancer-associated retinopathy (CAR) is one of the paraneoplastic neurological syndromes and characterised by retinal degeneration. Autoimmunity between cancer cells and retinal proteins is considered a major cause of CAR. The presence of serum autoantibodies to retinal antigens plays an important role in the diagnosis. A 60-year-old man reporting of visual disturbance and paresthaesia of extremities presented to our hospital. CT scan revealed a massive tumour in the left lower lobe of the lung. Small cell lung cancer was diagnosed histologically with bronchoscopy. Ophthalmological examination showed retinopathy but not optic neuritis. Anti-CV2/collapsin response mediator protein (CRMP)-5 and anti-Hu antibodies were detected by further serum examination. It has been reported that anti-CV2/CRMP5 antibodies are present in patients with neoplasms accompanied by retinopathy as well as optic neuritis. This is the first case of CAR with presence of anti-CV2/CRMP5 antibodies without neuritis.

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Small Cell Lung Cancer and Cancer-Associated Retinopathy

Cited by 4 publications

References 16 publications

Choroidal metastasis in a patient with small cell lung cancer discovered during treatment with chemotherapy

Choroidal metastasis in a patient with small cell lung cancer discovered during treatment with chemotherapy

Rétinopathies paranéoplasiques

Small cell lung cancer and progressive retinopathy

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