Small cell neuroendocrine carcinoma in the petrous apex

Abstract

With the exception of moderately differentiated neuroendocrine carcinoma of the larynx, neuroendocrine carcinomas are very rare head and neck malignancies. We report a case of a small cell neuroendocrine carcinoma in the petrous apex of the temporal bone. This unusual site for this tumour has not yet been reported in the literature. We confirmed the location and extent of the primary tumour by positron-emission tomography scan. The final histopathological diagnosis was of small cell carcinoma, and this was confirmed by immunohistochemistry. We treated this patient with surgery followed by radiotherapy and chemotherapy. After the treatment was completed there was subtotal remission of the tumour, with no distant metastases.

Primary and secondary small cell neuroendocrine carcinoma of the larynx: A review

“…1,2,4 The most common site of extrapulmonary SCNC is the esophagus. 5,6 SCNC also arises primarily in the head and neck region, 3,[7][8][9][10][11] where it most commonly involves the larynx. 12 The purpose of this article is to give the reader an overview about this unusual tumor of the larynx.…”

Primary small cell neuroendocrine carcinoma of the petrous apex: a report of an atypical case

“…Following three cycles of chemotherapy, imaging studies (PET scan and brain MRI) were performed and exhibited a stable disease. After the completion of his chemotherapy treatment, the patient underwent 30 radiotherapy sessions by intensity-modulated technique, targeting his mass, receiving a total radiation dose of 6,000 cGy (4)(5)(6). The brain MRI, repeated after 1 month after completion of radiotherapy, showed a stable tumor.…”