Small Cell Neuroendocrine Carcinoma of the Endometrium

Hoeven, K. H. Van; Hudock, Jude; Woodruff, James M.; Suhrland, Mark J.

doi:10.1097/00004347-199501000-00005

Cited by 105 publications

(107 citation statements)

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“…The neoplasm we report showed prominent neuroendocrine differentiation, including an extensive small cell neuroendocrine carcinoma component, with strong and consistent positivity for chromogranin A, synaptophysin, NSE and Leu-7. These findings could have been anticipated, in keeping with the Lauchlan theory, since, although sparsely mentioned, neuroendocrine differentiation has been recognized in uterine MMMTs (24,(31)(32)(33), as it has recently in an ovarian example (34). Some of these uterine MMMTs featured a small cell neuroendocrine carcinoma component, analogous to their infamous counterparts in the lung (32).…”

Section: Discussionsupporting

confidence: 63%

Primary Mesenteric Malignant Mixed Mesodermal (Müllerian) Tumor with Neuroendocrine Differentiation

Cokelaere¹,

Michielsen

Vos³

et al. 2001

Modern Pathology

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Extragenital malignant mixed mesodermal (mülle-rian) tumors (MMMT) are rare neoplasms, with but 24 well documented cases in the literature. Neuroendocrine differentiation in mixed müllerian neoplasms has been mentioned only anecdotally. We report on the clinical, pathological, and immunohistochemical features of a hitherto-undescribed extragenital MMMT with prominent neuroendocrine differentiation arising from the jejunal mesentery. This lesion was composed of a poorly differentiated epithelial component and a spindle cell component with heterologous (rhabdomyoblastic) differentiation. The bulk of the tumor consisted of small cell neuroendocrine carcinoma, which exhibited strong immunoreactivity for NSE, LEU-7, chromogranin A and synaptophysin. Electronmicroscopy confirmed the presence of neurosecretory dense-core granules. The primary mesenteric origin of the tumor was established at autopsy. Along with a brief review of previously reported extragenital MMMT some histogenetic concepts relevant to this case are discussed.

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Section: Discussionsupporting

confidence: 63%

Primary Mesenteric Malignant Mixed Mesodermal (Müllerian) Tumor with Neuroendocrine Differentiation

Cokelaere¹,

Michielsen

Vos³

et al. 2001

Modern Pathology

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“…The predominant component, SCC, fulfilled the three diagnostic criteria proposed by Van Hoeven et al [5]: no evidence of primary origin from the endometrium, characteristic histology with small-to intermediate-sized tumor cells growing in a dense, sheet-like fashion, and immune reactivity for the NE markers synaptophysin, CD56, and chromogranin A. As in our case, focal chromogranin A positivity was reported previously [10,12].…”

Section: Discussionsupporting

confidence: 83%

“…Metastatic tumor deposits were almost entirely composed of SCC, except that lymph node involvement was in serous carcinoma morphology. The present case favors the notion that SCC and serous carcinoma are the components with aggressive behavior in combined tumors of the endometrium [5,13].…”

Section: Discussionsupporting

confidence: 81%

“…In the endometrium, the SCC component is frequently combined with more differentiated tumors like endometrioid adenocarcinomas and serous carcinomas, and may also represent a component of malignant mixed Mullerian tumor (MMMT) [3]. A review of the literature revealed approximately 49 PD endometrial NETs (41 SCC, and 8 LCNEC), 22 of which were combined with endometrioid adenocarcinoma [4][5][6][7][8][9][10][11][12], 2 with adenosquamous carcinoma [6], 2 with serous carcinoma [13,14], and 3 were a component of an MMMT [3]. But to the best of our knowledge, the concomitant existence of SCC, endometrioid adenocarcinoma, and serous carcinoma arising in the endometrium has not been previously reported in the English literature.…”

Section: Introductionmentioning

confidence: 99%

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Small cell carcinoma in endometrium on the base of extensive adenomyosis: differential diagnosis with immunochemistry

et al. 2011

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Small cell carcinomas (SCCs) are rarely seen in the endometrium and usually present as a component of a combined tumor consisting of more differentiated endometrial tumors. SCCs commonly represent the deeply invasive and aggressive component of the tumor, and differentiating SCC from counterparts has a great importance in terms of different treatment modalities and worse prognosis. Differential diagnosis includes distinct tumors indistinguishable from SCC by histologic and morphologic features, and the definite diagnosis requires immunohistochemical proof of diffuse neuroendocrine differentiation. We present a case of combined endometrial tumor composed of SCC, endometrioid adenocarcinoma, and serous carcinoma, which was initially misdiagnosed as carcinosarcoma at another institute, and discuss the differential diagnosis in terms of clinicopathologic features.

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“…They ectopically produce endocrine non-hormonal biomarkers, biogenic amines and various polypeptide hormones [3][4][5][6]. In the endometrium, pure neuroendocrine cancers are very rare, and are more frequently recognized in the ovaries and uterine cervix [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Expression of neuroendocrine markers in endometrial carcinomas — an immunohistochemical analysis

Kędzia

Rajpert-Kędzia

2012

Folia Histochem Cytobiol.

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Abstract:The main aim of this study was the analysis of undifferentiated cancers and mixed ones positive for neuroendocrine biomarkers without morphological features -typical for this type of cancer. The obtained results indicated the necessity for neuroendocrine marker tests in undifferentiated cancers and mixed ones. Immunopositive results revealed enhanced malignancy of these cancers and the necessity for additional chemotherapy.

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Small Cell Neuroendocrine Carcinoma of the Endometrium

Cited by 105 publications

References 0 publications

Primary Mesenteric Malignant Mixed Mesodermal (Müllerian) Tumor with Neuroendocrine Differentiation

Primary Mesenteric Malignant Mixed Mesodermal (Müllerian) Tumor with Neuroendocrine Differentiation

Small cell carcinoma in endometrium on the base of extensive adenomyosis: differential diagnosis with immunochemistry

Expression of neuroendocrine markers in endometrial carcinomas — an immunohistochemical analysis

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