Small cell neuroendocrine tumour of the anterior tongue: A case report

Cymerman, James; Kulkarni, Raghav; Gouldesbrough, D. R.; McCaul, James

doi:10.1016/j.ijscr.2013.04.028

Cited by 18 publications

(12 citation statements)

References 8 publications

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“…The subject showed a 5 mm diameter ulcerated wound on the lateral border of the tongue, immunohistochemical analyses of biopsy revealed the typical features of a poorly differentiated neuroendocrine carcinoma of small cell type. The tumor cells were strongly positive for neuroendocrine markers including chromogranin A, synaptophysin and CD56 (27).…”

Section: Neuroendocrine Markers In Oral Cancersmentioning

confidence: 99%

From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases

et al. 2019

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The neuroendocrine system consists of various cells distributed in non-endocrine functional structures, able to synthesize amines and peptides with both local (paracrine) and systemic (endocrine) effects. The presence of such cells, belonging to the neuroendocrine system, is highlighted by the presence of neuroendocrine markers: the most suggestive are chromogranin A, synaptophysin, S-100B protein and glial fibrillary acidic protein. The presence of neuroendocrine markers is commonly associated to the occurrence of neuroendocrine cancers, currently representing the 0.5 percent of all malignant tumors. Nevertheless, neuroendocrine markers have been found to be overexpressed in rare oral neuroendocrine tumors, but also in quite common inflammatory conditions, such as severe periodontitis. The monitoring of neuroendocrine markers is, thus, a common factor of interest among dentistry and neurology: the analysis of neuroendocrine markers in oral diseases may be predictive and prognostic about the severity of neurological diseases, such as lateral amyotrophic sclerosis and traumatic brain injuries. The aim of this mini-review is to highlight the role of neuroendocrine molecules as advantageous diagnostic and prognostic markers for both oral diseases and neurodegenerative disorders.

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Section: Neuroendocrine Markers In Oral Cancersmentioning

confidence: 99%

From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases

et al. 2019

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“…SNEC of the head and neck exhibits a preference for males, with a peak incidence from the fifth to seventh decades of life, and occurs most frequently in men with a heavy smoking background (3)(4)(5)(6)(7)(8)(9). Patients typically present with painless masses and symptoms similar to other mucosal-based carcinomas at such sites.…”

Section: Introductionmentioning

confidence: 99%

“…Primary SNEC of the oral cavity is a rare neoplasm with only five cases reported in the English-language literature to date (4)(5)(6)(7)(8). This paucity of data means that a definitive therapeutic strategy has yet to be determined.…”

Section: Introductionmentioning

confidence: 99%

Primary small cell neuroendocrine carcinoma of the oral cavity: A case report and review of the literature

et al. 2015

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Abstract. Small cell neuroendocrine carcinoma (SNEC) of the oral cavity is a rare and distinctive tumor with aggressive clinical behavior. Thus far, only a small number of cases have been reported and no definitive standard treatment strategy has been determined. The current study reports a case of oral SNEC arising in the lower gingiva in a 73-year-old male. Computed tomography displayed a relatively well-defined mass measuring 2.8x2x1.4 cm in size. The mass was located in the buccal side of the right mandibular posterior gingiva and exhibited no bony involvement. Histopathological examination revealed a proliferation of small cells with ovoid-to spindle-shaped nuclei, fine granular chromatin, inconspicuous nucleoli, scant cytoplasm and high mitotic activity. Immunohistochemically, the tumor cells were positive for cytokeratin AE1/AE3, chromogranin A, synaptophysin and neuron-specific enolase. Surgical resection and radical neck dissection were performed prior to the administration of adjuvant chemotherapy with a combination of cisplatin and etoposide. No evidence of local recurrence or metastasis was observed at 14 months post-surgery.

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“…To date only four cases of small cell/high-grade neuroendocrine tumour of the tongue have been reported [1–4]. …”

Section: Introductionmentioning

confidence: 99%

A rare case and literature review of primary neuroendocrine carcinoma of the tongue

Singla

Gallagher

2014

Journal of Surgical Case Reports

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Neuroendocrine tumours are rare and have been reported to arise in a number of structures within the head and neck. We present the case of a 55-year-old lady who presented a T1-N2-M0 neuroendocrine tumour of the tongue and right level 2A lymphadenopathy. The patient underwent a partial right-sided glossectomy and a modified radical neck dissection. Given the rarity of small cell neuroendocrine tumours of the tongue, there is some ambiguity with respect to classification. Treatment for neuroendocrine tumours is most effective with a multimodality approach and a poor response to chemotherapy is an important prognostic indicator. Radiotherapy, combined with chemotherapy, has shown the most promise with complete resolution of the primary tumour and metastatic disease. Due to the rarity of neuroendocrine tumours and the lack of favourable prognostic indicators, defining optimal treatment remains difficult. As a result, they continue to have a poor overall prognosis.

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Small cell neuroendocrine tumour of the anterior tongue: A case report

Cited by 18 publications

References 8 publications

From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases

From Mouth to Brain: Neuroendocrine Markers Play as a Crosstalk Among Oral and Neurodegenerative Diseases

Primary small cell neuroendocrine carcinoma of the oral cavity: A case report and review of the literature

A rare case and literature review of primary neuroendocrine carcinoma of the tongue

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