Small cell nonkeratinizing carcinoma of the cervix associated with acth production

Jones, Howard W.; Plymate, Stephen R.; Gluck, Frank B.; Miles, Philip A.; Greene, John F.

doi:10.1002/1097-0142(197610)38:4<1629::aid-cncr2820380431>3.0.co;2-i

Cited by 70 publications

(7 citation statements)

References 9 publications

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“…Many authors have reported cervical carcinomas containing endocrine cells (Tateishi et al 1975, Albores-Saavedra et al 1979, Miles et al 1982. Some of these tumours elaborated hormonal products such as serotonin, ACTH, p-MSH and insulin (Kiang, Bauer & Kennedy 1973, Jones et al 1976, Matsuyama et al 1979, Lojek et al 1980. Most of these neoplastic processes are not true carcinoids but carcinomas exhibiting focal endocrine differentiation.…”

Section: Discussionmentioning

confidence: 99%

Endocrine cells in the female genital tract

et al. 1985

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Endocrine cells are normal inhabitants of the para-urethral, Bartholin's and endocervical glands and of mesonephric rests. All these cells were characterized as serotonin-storing cells. In the para-urethral and Bartholin's glands, serotonin-containing cells were most often found in the transitional epithelium of excretory ducts. Endocrine cells participated in some pathological conditions. Abundant argentaffin cells were observed among the terminal ductules in chronic bartholinitis and serotonin-storing cells were identified in a peculiar ectocervical epithelium. Numerous serotonin-storing cells were detected in a well-differentiated adenocarcinoma of cervix occurring in a patient with the Peutz-Jeghers syndrome. Argyrophilic cells were present in cases of endometrial carcinomas; a striking feature was the demonstration of gut peptide hormones in an unusual type of endometrial adenocarcinoma. Finally, serotonin-storing cells were a constituent of Brenner tumours. It is suggested that a similar endocrine pattern may be shared by tissues originating from both Müllerian ducts and the urogenital sinus.

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Section: Discussionmentioning

confidence: 99%

Endocrine cells in the female genital tract

et al. 1985

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“…De hecho, constituye el tipo tumoral menos prevalente dentro de los carci- 2 refirieron el primer caso de localización larín-gea, incidiendo en su identidad histológica con el carcinoma de células pequeñas de localización pulmonar. Asimismo, se han descrito otras localizaciones extrapulmonares, a saber: piel, páncreas y cérvix uterino, [3][4][5] con incidencias (en torno al 4%) muy por debajo de las descritas para el pulmón.…”

Section: Discussionunclassified

Carcinoma neuroendocrino de células pequeñas de la región nasosinusal

González-García

Nam-Cha

Campo

et al. 2006

Rev Esp Cirug Oral y Maxilofac

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Paciente de 70 años con antecedentes de fibrosis pulmonar y artritis reumatoide en tratamiento, acudió a nuestra consulta remitido desde el Servicio de Oftalmología, por presentar dolor e inflamación a nivel de región lateronasal y párpado inferior izquierdos de más de un mes de evolución, con diplopia en la mirada lateral extrema. A pesar del tratamiento previo antibiótico y antiinflamatorio por vía oral, no experimentó mejoría del cuadro. A la exploración física presentaba exoftalmos del ojo izquierdo, con dificultad en la mirada conjugada, inflamación, eritema y dolor de región lateronasal izquierda y edema palpebral inferior izquierdo (Fig. 1). Ante la posibilidad inicial de cuadro de celulitis orbitaria y ausencia de diagnóstico definitivo, se decidió ingreso para tratamiento anti- 2006;28,6 (noviembre-diciembre):368-372 A cervicofacial computed tomography (CT scan) was carried out with axial and coronal cuts that revealed a mass Página del ResidenteRev Esp Cir Oral y Maxilofac

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“…Subsequently, other cases were reported under various terms, such as "apudoma" [8], "argyrophil carcinoma" [8,9], "oat cell carcinoma" [10], "neuroendocrine carcinoma" [2], and "small cell non-keratinizing carcinoma" [11]. These neoplasms demonstrated a broad spectrum of differentiation ranging from well-differentiated forms resembling carcinoid tumors to poorly differentiated forms exhibiting a histologic image comparable to small-cell carcinoma of the lung [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…Anti-neuron specific enolase (NSE) Owing to the rarity of hormone-secreting neoplasms in the cervix, only a few cases of cervical neuroendocrine tumors have been described. Some of these tumors elaborated hormonal substances such as ACTH, Beta-melanocyte-stimulating hormone (Beta-MSH), insulin, serotonin, and calcitonin [11,15,16]. Pearse [171, who introduced the APUD concept (amine precursor uptake and decarboxylation), believed that this category of cells originated from the neural crest and that they shared a number of ultrastructural and cytochemical characteristics 118].…”

Section: Discussionmentioning

confidence: 99%

Resident Neuroendocrine Cells in the Normal Ectoendocervical Epithelium

Remadi¹,

MacGee²,

Megevand³

et al. 1997

Int J Surg Pathol

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Among the major difficulties in determining the histogenesis of small-cell neuroendocrine carcinomas of the cervix is the issue of identifying the cell from which the neoplasm arises. In this study we performed an immunohistochemical analysis of the neuroendocrine cells in the normal ectoendocervical epithelium by using a microwave heating technique. In ectocervical epithelium, positivity for chromogranin and/or neuron-specific enolase was detected in 18% of the cases, whereas 46% of the endocervical mucosae demonstrated immunoreactive cells for these antibodies. Isolated endocervical neuroendocrine cells showed immunoreactivity for antigastrin (1 case), anti-VIP (3 cases), and antisynaptophysin (14 cases) antibodies. A comparative analysis of 4 diagnosed cases of small-cell carcinoma of the cervix demonstrated immunoreactivity for neuron-specific enolase and chromogranin, respectively, in 3 cases and for synaptophysin in 1 case. Thus, small-cell carcinoma of the cervix likely originates from cells with neuroendocrine differentiation localized mainly in the endocervical glands. These findings offer an explanation for the paraneoplastic syndromes described in some cases of small-cell carcinoma of the cervix. Int J Surg Pathol 5(1/2): [19][20][21][22][23][24] 1997

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Small cell nonkeratinizing carcinoma of the cervix associated with acth production

Cited by 70 publications

References 9 publications

Endocrine cells in the female genital tract

Endocrine cells in the female genital tract

Carcinoma neuroendocrino de células pequeñas de la región nasosinusal

Resident Neuroendocrine Cells in the Normal Ectoendocervical Epithelium

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