Small cutaneous wounds induce telogen to anagen transition of murine hair follicle stem cells

Jiang, Shu; Zhao, Lu; Teklemariam, Takele; Hantash, Basil M.

doi:10.1016/j.jdermsci.2010.10.008

Cited by 21 publications

(16 citation statements)

References 37 publications

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“…4B). These findings are consistent with previous studies in which the expression levels of hair induction-related genes were upregulated in hair regrowth (24,32). The data demonstrate that CXCL4 mAb activates the Wnt/β-catenin- and Bmp-signaling pathways to mediate hair regeneration.…”

Section: Discussionsupporting

confidence: 93%

Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice

Guan

et al. 2017

Experimental and Therapeutic Medicine

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Although hair loss or alopecia is a common disease, its exact mechanisms are not yet well understood. The present study investigated the hypothesis that the homeostatic regulation of genes during hair regeneration may participate in hair loss, based on the cyclicity of hair growth. A cluster of such genes was identified by an expression gene-array from the dorsal skin in a depilated mouse model, and CXCL4 was identified as a significantly regulated gene during the hair regeneration process. To elucidate the function of CXCL4 in hair growth, CXCL4 activity was blocked by the administration of an anti-CXCL4 monoclonal antibody (mAb). Histomorphometric analysis indicated that anti-CXCL4 mAb induced an earlier anagen phase and delayed hair follicle regression, in contrast with that in the control group. Moreover, CXCL4 mAb upregulated the transcription levels of several hair growth-related genes, including Lef1, Wnt10b, Bmp4 and Bmp2. In addition, CXCL4 mAb increased the levels of the proliferation-related protein PCNA and Bcl-2 during the anagen phase, while it reduced the expression of pro-apoptotic protein Bax and cleaved caspase-3 during the catagen phase. These findings reveal that CXCL4 plays an important role in hair growth, and that blockade of CXCL4 activity promotes hair growth.

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Section: Discussionsupporting

confidence: 93%

Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice

Guan

et al. 2017

Experimental and Therapeutic Medicine

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“…Tcf3 has been reported to be upregulated in day 26 post-wounded skin 24 , and overexpression of Snail1, which promotes cell migration, also induces Tcf3 expression 25 . Although these two correlative findings suggest that Tcf3 might play a role in wound repair and cell migration, Tcf3’s exact role in cell migration and wound repair is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2

Miao

Nishino

et al. 2014

Nat Commun

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Cell migration is an integral part of re-epithelialization during skin wound healing, a complex process involving molecular controls that are still largely unknown. Here we identify a novel role for Tcf3, an essential transcription factor regulating embryonic and adult skin stem cell functions, as a key effector of epidermal wound repair. We show that Tcf3 is upregulated in skin wounds and that Tcf3 overexpression accelerates keratinocyte migration and skin wound healing. We also identify Stat3 as an upstream regulator of Tcf3. We show that the pro-migration effects of Tcf3 are non-cell autonomous and occur independently of its ability to interact with β-catenin. Finally, we identify lipocalin-2 as the key secreted factor downstream of Tcf3 that promotes cell migration in vitro and wound healing in vivo. Our findings provide new insights into the molecular controls of wound-associated cell migration and identify potential therapeutic targets for the treatment of defective wound repair.

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“…Previous studies have shown that activation of the Wnt/β-catenin, Shh, and bone morphogenetic protein signaling pathways is critical for anagen induction and hair growth (Cotsarelis and Millar, 2001;Schneider et al, 2009;Jiang et al, 2010). Foxe1 and Ptch1 are downstream target genes of the Shh pathway in hair growth (Brancaccio et al, 2004).…”

Section: Downregulation Of the Hair Growth-related Genes With Anti-s1mentioning

confidence: 99%

Blockade of S100A3 activity inhibits murine hair growth

Guan¹,

Deng²,

Yu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Using mouse gene expression microarray analysis, we obtained dynamic expression profiles of the whole genome in a depilationinduced hair growth mouse model. S100A3 expression increased during the anagen phase and returned to normal during the telogen phase. The effects of S100A3 blockade on the hair growth cycle were examined in mice after subcutaneous injection of an anti-mouse S100A3 antibody. Protein localization of S100A3 was confined to the hair shafts during the anagen phase and the sebaceous glands during the telogen phase. S100A3 blockade delayed hair follicle entry into the anagen phase, decreased hair elongation, and reduced the number of hair follicles in the subcutis, which correlated with the downregulated expression of hair growth inductionrelated genes in vivo. The present study demonstrates that anti-S100A3 antibody inhibits mouse hair growth, suggesting that S100A3 can be used as a target for hair loss treatment.

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Small cutaneous wounds induce telogen to anagen transition of murine hair follicle stem cells

Cited by 21 publications

References 37 publications

Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice

Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice

Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2

Blockade of S100A3 activity inhibits murine hair growth

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