Small diameter Polyurethane vascular graft reinforced by elastic weft-knitted tubular fabric of polyester/spandex

Xu, Weilin; Zhou, Fei; Ouyang, Chenxi; Cui, Weigang; Mu, Yao; Wang, Xungai

doi:10.1007/s12221-008-0011-7

Cited by 12 publications

(8 citation statements)

References 32 publications

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“…Improvements have been achieved with polyurethane-based materials, where tubular constructs have shown enhanced compliance over the currently used synthetic grafts [6]. Xu et al [7] fabricated small diameter vascular grafts using polyurethane reinforced with a tubular weft-knitted fabric. Although the tensile properties of the reinforced grafts were improved compared with the pure polyurethane constructs, these grafts required a very specific weft-knitting machine to fabricate the knitted tube, and therefore reproducibility becomes a concern.…”

Section: Introductionmentioning

confidence: 99%

Mechanical properties of cellulose: chitosan blends for potential use as a coronary artery bypass graft

Azevedo

Retarekar

Raghavan

et al. 2012

Journal of Biomaterials Science, Polymer Edition

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The development of intimal hyperplasia is the major cause of failure of both autologous saphenous vein and synthetic coronary artery bypass grafts. This is partially due to graft-host vessel compliance mismatch. Cellulose and chitosan (CELL:CHIT) are both biocompatible, nontoxic, and naturally occurring biopolymers that have been used extensively for biomedical applications. Elastic properties of membranes made of CELL:CHIT blends with different ratios between each polymer were determined using uniaxial tests and the ratio that yielded the less stiff membrane was chosen to prepare a small diameter hollow tube. The presence of chitosan had a favorable impact on the elasticity of the membranes, where the CELL:CHIT 5:5 ratio showed the lowest Young's modulus. Small diameter tubular constructs were fabricated using this optimal CELL:CHIT ratio and the compliance was determined on samples with different wall thickness and internal diameter. The compliance of the hollow tube with inner diameter of 4 mm and wall thickness of 1.2 mm was found to be 5.91%/mmHg×10(-2), which is higher than those of Dacron, expanded polytetrafluorethylene, and saphenous vein, but very close to that of human coronary artery. Burst strength tests revealed that the tubes can withstand at least 300 mmHg. Finally, the tubes showed satisfactory cell attachment property when myofibroblast cells adhered and proliferated on the lumen of the samples.

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Section: Introductionmentioning

confidence: 99%

Mechanical properties of cellulose: chitosan blends for potential use as a coronary artery bypass graft

Azevedo

Retarekar

Raghavan

et al. 2012

Journal of Biomaterials Science, Polymer Edition

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“…However, the histocompatibility of modified PU material varies when mixed with various SF powders at different ratio. A composite of superfine SF powder and PU material at a ratio of 1 : 1 had mechanical properties close to those of human arteries, and at this ratio the histocompatibility of the material was optimal . SF–PU (1 : 1) also showed a better histocompatibility in the acute phase than some established macromolecule biomaterials, such as Dacron, pure PU, and e‐PTFE .…”

Section: Discussionmentioning

confidence: 90%

“…Preliminary results suggested that the small diameter SF–PU graft reinforced with elastic tubular fabric had appropriate flexibility and enhanced physical properties close to human blood vessels …”

Section: Discussionmentioning

confidence: 99%

“…The material used in this research was a blend film composed of SF, PU, and aspirin and was made by using the phase separation technique . Our previous research exhibited that the SF–PU (1 : 1) possessed good physical properties . Moreover, the hybrid film in combination with controlled released aspirin not only had good mechanical properties, but also could reduce inflammation .…”

Section: Introductionmentioning

confidence: 99%

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Improvement of histocompatibility of silk fibroin/polyurethane membrane with controlled release of aspirin

Wang

Yang

et al. 2014

J of Applied Polymer Sci

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The histocompatibility of polyurethane (PU) modified by superfine silk-fibroin (SF) powder (1 : 1) with different dosage of aspirin to determine the best dosage for histocompatibility was investigated. Aspirin powder was incorporated into SF-PU (1 : 1) blend mixture at doses of 0%, 5%, or 10% (w/w). The influence of different doses of aspirin on histocompatibility of the hybrid material was studied by using morphology examination, infrared spectroscopy, in vitro drug release study, and in vivo tests including an acute toxicity test, an assessment of local reaction in the muscle, hematological examination, and histological examination. SF-PU (50 : 50) blend film had superior performance over the polytetrafluoroethylene (e-PTFE) film in terms of histocompatibility, and the anti-inflammatory/anti-platelet effects were improved after integration with limited doses of aspirin to yield a valuable drug release vascular graft.

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“…This design concept improved the development of vascular grafts, which may be fabricated to be microporous and elastomeric, coaxial or triple‐tubular, using different types of materials with complementary properties. A coaxial three‐layer polyurethane vascular graft reinforced by weft‐knitted tubular fabric has been successfully fabricated via phase separation technique in our laboratory for improving suture and mechanical properties 28–30. The aim of this study was to investigate the effect of weft‐knitted tubular fabric on the radial mechanical property of the coaxial three‐layer polyurethane vascular grafts.…”

Section: Introductionmentioning

confidence: 99%

Influence of weft‐knitted tubular fabric on radial mechanical property of coaxial three‐layer small‐diameter vascular graft

et al. 2011

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The goal of this study was to evaluate the radial mechanical property of the small-diameter polyurethane vascular grafts reinforced by weft-knitted tubular polyester/spandex fabrics. The polyester/spandex tubular fabrics with different blend ratios were prepared on a weft-knitting machine to reinforce small-diameter polyurethane vascular grafts. Phase separation technique was employed to produce coaxial three-layer small-diameter polyurethane vascular grafts at room temperature. Morphology of the polyurethane vascular grafts was examined by scanning electron microscope (SEM), and micropores were observed on both inner and cross section surfaces. Radial tensile property and compliance of small-diameter polyurethane vascular grafts with and without reinforcement by polyester/spandex tubular fabrics were characterized. The effect of polyester/spandex tubular fabric on the mechanical property of polyurethane vascular grafts was studied. The results indicated that the radial tensile strength of the vascular graft was improved by the tubular fabric, and that the influence of tubular fabric on compliance was small compared to that of wall thickness. It was notable that the wall thickness of the vascular grafts was a major factor in controlling the compliance in the radial direction. Therefore, a coaxial three-layer small-diameter polyurethane vascular graft with excellent compliance and tensile strength could be obtained by controlling the wall thickness and using polyester/spandex fabric as reinforcement.

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Small diameter Polyurethane vascular graft reinforced by elastic weft-knitted tubular fabric of polyester/spandex

Cited by 12 publications

References 32 publications

Mechanical properties of cellulose: chitosan blends for potential use as a coronary artery bypass graft

Mechanical properties of cellulose: chitosan blends for potential use as a coronary artery bypass graft

Improvement of histocompatibility of silk fibroin/polyurethane membrane with controlled release of aspirin

Influence of weft‐knitted tubular fabric on radial mechanical property of coaxial three‐layer small‐diameter vascular graft

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