Small, flat colorectal cancers in the UK population: an analysis of resected specimens

Tweedle, E; Chaudhri, Sanjay; Azadeh, Bahram; Rooney, Paul

doi:10.1111/j.1463-1318.2006.01205.x

Cited by 9 publications

(4 citation statements)

References 40 publications

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“…In contrast to colon polyps that can easily be detected through colonoscopy, chronic colitis can result in dysplastic lesions that are difficult to identify. Flat colorectal adenoma is associated with accelerated carcinogenesis (3,4) and poor prognosis (5). Given the negative outcome linked with colitis-associated colon cancer (CACC), prevention strategies aimed at reducing inflammation in individuals with IBD may reduce cancer risk.…”

Section: Introductionmentioning

confidence: 99%

Dietary Fish Oil Alters T Lymphocyte Cell Populations and Exacerbates Disease in a Mouse Model of Inflammatory Colitis

et al. 2010

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Inflammatory bowel diseases (IBD) increase the risk of developing colorectal cancer. Dietary components that reduce inflammation are associated with lower cancer risk. The long-chain omega-3 fatty acid docosahexaenoic acid (DHA) is present in fish oil and has potent anti-inflammatory properties. The objective of this study is to determine whether dietary fish oil enriched with DHA (DFO) could reduce experimentally induced colitis and colon cancer risk in a mouse model. When SMAD3−/− mice are exposed to Helicobacter hepaticus, mild colitis is observed 4 weeks postinfection. Mice were fed isocaloric diets modified to include corn oil, safflower oil, or DFO (doses ranging from 0.75% to 6.00%) as the fatty acid source for 8 weeks. Mice were gavaged with H. hepaticus; DFO feeding was continued; and mice were sacrificed 4 weeks after infection. The colon and cecum were collected for histopathology. Spleens and mesenteric lymph nodes were collected and analyzed for T-cell populations using flow cytometry. Contrary to expectations, DFO induced severe colitis and adenocarcinoma formation. DFO consumption was associated with decreased CD8 + cell frequency and diminished CD69 expression on CD4 + and CD8 + T-cell populations. Mice consuming DFO also exhibited higher FoxP3 + CD25 + CD4 + T regulatory cell frequency, FoxP3 expression, and altered L-selectin expression during infection. We concluded that DFO-fed mice may be less equipped to mount a successful response to H. hepaticus infection, increasing colon cancer risk. These results support the need to establish a tolerable upper limit for DHA intake particularly in the context of chronic inflammatory conditions such as IBD.

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Section: Introductionmentioning

confidence: 99%

Dietary Fish Oil Alters T Lymphocyte Cell Populations and Exacerbates Disease in a Mouse Model of Inflammatory Colitis

et al. 2010

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“…This is supported by many reports in the Japanese literature 2, 3 with more variation in the Western published reports 4-10. Yashiro et al provided molecular evidence to suggest that de-novo cancers may arise from these morphologically distinct lesions11.…”

Section: Introductionmentioning

confidence: 76%

Association of smoking and flat adenomas: results from an asymptomatic population screened with a high-definition colonoscope

Anderson

Stein

Kahi³

et al. 2010

Gastrointestinal Endoscopy

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Background-Flat adenomas represent a morphologically distinct class of polyps that may be difficult to detect but little is known regarding risk factors for these lesions. Identification of risk factors for these lesions may aid in colorectal cancer (CRC) screening since patients at risk for these lesions may require special imaging techniques. Smoking, an important risk factor for CRC, may be associated with molecular changes that increase the risk for flat adenomas.

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“…As the reported sensitivity and specificity of CTC for the detection of adenomas or cancers measuring .10 mm were 90% and 86%, respectively, its diagnostic capability is sufficiently high for screening an average-risk population (6). However, the detection of flat polyps is important at colorectal cancer screening because small flat lesions are more likely to be stage T3/T4 than polypoid lesions that tend to be stage T1 (15). In our study the detection sensitivity for flat polyps (.2 mm) was 47.6%, for polypoid lesions it was 64.1%.…”

Section: Discussionmentioning

confidence: 99%

Detection of flat colorectal polyps at screening CT colonography in comparison with conventional polypoid lesions

et al. 2012

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Small, flat colorectal cancers in the UK population: an analysis of resected specimens

Abstract: The prevalence of small, flat cancers in resected specimens in the UK concurs with that of Japanese studies. Small, flat cancers should be staged carefully because of high rates of T3/4 disease. The results support the theory of accelerated carcinogenesis in flat cancers.

Cited by 9 publications

References 40 publications

Dietary Fish Oil Alters T Lymphocyte Cell Populations and Exacerbates Disease in a Mouse Model of Inflammatory Colitis

Dietary Fish Oil Alters T Lymphocyte Cell Populations and Exacerbates Disease in a Mouse Model of Inflammatory Colitis

Association of smoking and flat adenomas: results from an asymptomatic population screened with a high-definition colonoscope

Detection of flat colorectal polyps at screening CT colonography in comparison with conventional polypoid lesions

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