Small functionalized iron oxide nanoparticles for dual brain magnetic resonance imaging and fluorescence imaging

Wei, Ruixue; Liu, Yang; Gao, Jinhao; Yong, V. Wee; Xue, Mengzhou

doi:10.1039/d0ra10392f

Cited by 10 publications

(4 citation statements)

References 42 publications

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“…[42] Particularly, multimodal imaging methods based on NIR fluorescence, MRI, and SERS have received increasing attention in diagnosis and treatment of major brain diseases due to their excellent penetration depth, sensitivity, and so on. [43,44] Portnoy et al used bifunctional fluorescent/ magnetic nanoparticles (NPs) to track inflammation in the brains of epileptic mice. [45] After injection of magnetite and borondipyrromethene (BODIPY) dual-labeled magnetic NPs (MNPs) into lithium-moronic acid-induced chronic epileptic mice via tail vein, MNPs were able to identify activated immune cells accumulating in epileptogenic tissue, providing a powerful tool for preoperative detection of EF and imaging-guided surgical treatment.…”

Section: Multimodal Imagingmentioning

confidence: 99%

Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Zhao,

Ngai,

Wang

et al. 2024

Small Structures

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The treatment of neurological disease, such as epilepsy is rather complicated. Emerging therapies such as surgery, gene therapy, stem cell transplantation, and neurostimulation have been developed to replace traditional drug therapy. However, great challenges such as the difficult localization of epileptic foci (EF), incomplete excision of lesioned nerves, high drug resistance, and severe side effects limit their clinical applications. As an alternative, bioinorganic materials have been emerged and show great potentials for epilepsy theranostics. Their unique physical properties, including fluorescence, magnetic resonance effect, and surface‐enhanced Raman scattering effect (SERS), give them the ability to image the localization of EF. In addition, the fluorescence and conductivity of bioinorganic materials could be further used for studying pathogenesis. Moreover, bioinorganic materials could serve as intelligent systems to deliver drugs and cooperative therapy for epilepsy. Herein, this review highlights the design and application of bioinorganic materials in the imaging, diagnosis, and therapy of epilepsy. Furthermore, light is shown on the potential bottlenecks and future perspectives of bioinorganic materials in epilepsy theranostics.

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Section: Multimodal Imagingmentioning

confidence: 99%

Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Zhao,

Ngai,

Wang

et al. 2024

Small Structures

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“…This was further modified with the retro-enantiomer of Angiopep-2 to prevent its degradation by enzymes of the blood and cells. In keeping with the idea of dual-modal imaging, Wei and colleagues [150] introduced small-sized iron oxide NPs (SIONs), which were surface modified with Angiopep-2 and the photosensitizer, chlorin e6, to boost fluorescence imaging to support MRI results.…”

Section: Diagnostic and Theranostic Applicationsmentioning

confidence: 99%

Angiopep-2-Modified Nanoparticles for Brain-Directed Delivery of Therapeutics: A Review

Habib

Singh

2022

Polymers

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Nanotechnology has opened up a world of possibilities for the treatment of brain disorders. Nanosystems can be designed to encapsulate, carry, and deliver a variety of therapeutic agents, including drugs and nucleic acids. Nanoparticles may also be formulated to contain photosensitizers or, on their own, serve as photothermal conversion agents for phototherapy. Furthermore, nano-delivery agents can enhance the efficacy of contrast agents for improved brain imaging and diagnostics. However, effective nano-delivery to the brain is seriously hampered by the formidable blood–brain barrier (BBB). Advances in understanding natural transport routes across the BBB have led to receptor-mediated transcytosis being exploited as a possible means of nanoparticle uptake. In this regard, the oligopeptide Angiopep-2, which has high BBB transcytosis capacity, has been utilized as a targeting ligand. Various organic and inorganic nanostructures have been functionalized with Angiopep-2 to direct therapeutic and diagnostic agents to the brain. Not only have these shown great promise in the treatment and diagnosis of brain cancer but they have also been investigated for the treatment of brain injury, stroke, epilepsy, Parkinson’s disease, and Alzheimer’s disease. This review focuses on studies conducted from 2010 to 2021 with Angiopep-2-modified nanoparticles aimed at the treatment and diagnosis of brain disorders.

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“…With advancements in all domains of technology and industry, new nanoscale materials with distinct chemical and physical properties have been discovered [19,20]. To improve the sensitivity of the analytical detection of various sensing probes, nanomaterials such as noble metals, quantum dots, nanocomposites, and nanometal oxides have been used as alternatives to standard fluorophores [21][22][23][24]. To increase the fluorescence intensity, nanostructures have also been used as sensor substrates.…”

Section: Introductionmentioning

confidence: 99%

Biogenic synthesis of ZnO and Al2O3 nanoparticles using Camellia sinensis and Origanum vulgare L. leaves extract for spectroscopic estimation of ofloxacin and ciprofloxacin in commercial formulations

Alarfaj,

Alabdulmonem,

Al-Onazi

et al. 2023

PLoS ONE

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The current study describes the biogenic synthesis of two metal oxides zinc oxide (ZnO), aluminum oxide (Al2O3) nanoparticles using Camellia sinensis, and Origanum vulgare L. leaves extract, respectively. The synthesized metal oxide nanoparticles were investigated using spectroscopic and microscopic techniques to confirm the formation of their nanostructures. Accurate and precise spectrofluorometric probes were proposed for the quantification of Ofloxacin (OFX) and Ciprofloxacin (CPFX) in their bulk and commercial formulations. The extraordinary properties of Zinc oxide and aluminum oxide nanoparticles (ZnONPs and Al2O3NPs) enhance the fluorescence intensity in the presence of 0.5 mL and 1.0 mL of sodium dodecyl sulfate (SDS, 1.0% w/v) as organizing agent for the detection of OFX and CPFX, respectively. The optical detection of both drugs at λex/em range 250–700 nm displayed linearity with a main correlation coefficient >0.999 at 1–300 (OFX-SDS-ZnONPs) and 0.5–100 (OFX-SDS-Al2O3NPs) ng mL-1,10–400 (CPFX-SDS-ZnONPs) and 0.1–50 (CPFX-SDS-Al2O3NPs) ng mL-1. The detection and quantification limits were found to be 0.04, 0.03, and 0.02, 0.04 ng mL-1, 0.13, 0.10, and 7.24, 0.09 ng mL-1 for the above-mentioned fluorescence systems, respectively. The suggested spectrofluorometric probes were validated and potentially applied for the estimation of OFX and CPFX in their bulk and commercial formulations.

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Small functionalized iron oxide nanoparticles for dual brain magnetic resonance imaging and fluorescence imaging

Abstract: SIONs is modified with brain targeting ligands and photosensitizers, and is used for in vivo MR/FL dual-mode high-sensitivity brain imaging.

Cited by 10 publications

References 42 publications

Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Angiopep-2-Modified Nanoparticles for Brain-Directed Delivery of Therapeutics: A Review

Biogenic synthesis of ZnO and Al2O3 nanoparticles using Camellia sinensis and Origanum vulgare L. leaves extract for spectroscopic estimation of ofloxacin and ciprofloxacin in commercial formulations

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