2022
DOI: 10.1371/journal.pone.0279279
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Small hard drusen and associated factors in early seniority

Abstract: Purpose The purpose of this study was to examine the ocular and systemic risk profile of the fundus phenotype ≥ 20 small hard (macular) drusen (< 63 μm in diameter). Methods This single-center, cross-sectional study of 176 same-sex twin pairs aged 30 to 80 (median 60) years was a component of a framework study of the transition from not having age-related macular degeneration to having early AMD. Drusen categories assessed using fundus photography and optical coherence tomography included small hard druse… Show more

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Cited by 2 publications
(1 citation statement)
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“…Small drusen (hard drusen) are discrete yellow‐whitish deposits (<63 μm in diameter) with a clearly defined margin (Khan et al, 2016). In 2013 The Beckman group published guidance in which hard drusen or a few small drusen, called ‘druplets’, were considered a normal ageing process of the eye, because of the low probability (0.4%) in such eyes of progression to late AMD (Belmouhand et al, 2022; Ferris 3rd et al, 2013; Mitchell et al, 1995). Nevertheless, when small drusen accumulate in number over time, there is an increased risk of progression to intermediate AMD (Ferris 3rd et al, 2013).…”
Section: Risk Factorsmentioning
confidence: 99%
“…Small drusen (hard drusen) are discrete yellow‐whitish deposits (<63 μm in diameter) with a clearly defined margin (Khan et al, 2016). In 2013 The Beckman group published guidance in which hard drusen or a few small drusen, called ‘druplets’, were considered a normal ageing process of the eye, because of the low probability (0.4%) in such eyes of progression to late AMD (Belmouhand et al, 2022; Ferris 3rd et al, 2013; Mitchell et al, 1995). Nevertheless, when small drusen accumulate in number over time, there is an increased risk of progression to intermediate AMD (Ferris 3rd et al, 2013).…”
Section: Risk Factorsmentioning
confidence: 99%