Small Heat Shock Proteins HSP10 and HSP27 in the Left Ventricular Myocardium in Rats with Arterial Hypertension and Insulin-Dependent Diabetes Mellitus

The role of heat shock proteins in the pathogenesis of heart failure (Review)

“…This fact indicates that the activation of these proteins plays a maladaptive role in the activity of CMCs, which can serve as an important marker for assessing the progression of vascular damage in this type of pathology. A decrease in the expression of the HSP60/HSP10 complex relative to Bax was also found in all the pathological models studied, while this difference was less pronounced in the combined hypertension with DM group (43,98,143). Thus, a decrease in the production of HSP60 can be considered as one of the pathophysiological mechanisms of LV myocardial damage caused by hypertension and/or DM.…”

“…In the mentioned study, the expression of HSP27 in LV myocardium was also evaluated. In the group with longer duration of hypertension (SHR rats aged 57 weeks), the ratio of Bax and Bcl-2 was the most pronounced, while the level of HSP27 was also the highest in all groups, which may indicate the activation of protein defense mechanisms directed to Bax binding ( 43 , 98 , 143 ).…”

“…In a recently published study by Sklifasovskaya and Blagonravov ( 98 ), the results of assessment of HSP10 and HSP27 expression in rat LV myocardium in hypertension, DM and their combination were presented. In case of combination of hemodynamic overload and DM, small HSPs showed different expression levels in CMCs.…”

“…Expression of HSP10 and HSP27 in CMCs changed inversely in AH of different duration, insulin-dependent DM and their combination. Protein HSP27 may play a more important role in cardioprotection in long-term hypertension and protein HSP10 in the case of the combination of AH and DM ( 98 ).…”