2014
DOI: 10.1021/cr400615v
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Small Heterocycles in Multicomponent Reactions

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Cited by 865 publications
(358 citation statements)
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References 201 publications
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“…MCRs have been also applied in polymer [74], nucleoside [75] and carbohydrate [76] chemistry. Main field of application remains the production of heterocyclic compounds and many natural products by means of MCR [38,[77][78][79][80][81][82][83][84][85][86][87][88][89], leading directly towards drug design and discovery [90][91][92][93][94]. Scheme 9 presents a current brief of well-known multicomponent reactions [35,40,9,[95][96][97][98][99][100][101][102][103][104][105][106][107][108][109][110].…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…MCRs have been also applied in polymer [74], nucleoside [75] and carbohydrate [76] chemistry. Main field of application remains the production of heterocyclic compounds and many natural products by means of MCR [38,[77][78][79][80][81][82][83][84][85][86][87][88][89], leading directly towards drug design and discovery [90][91][92][93][94]. Scheme 9 presents a current brief of well-known multicomponent reactions [35,40,9,[95][96][97][98][99][100][101][102][103][104][105][106][107][108][109][110].…”
Section: Methodsmentioning
confidence: 99%
“…Scifinder) about the target products and intermediates of the synthesis plan. With respect to 1: New and in particular novel MCRs [38,45,61,82,83,114,115,[176][177][178][179][180][181][182] are the basis and guarantee for high diversity and therewith the capacity to produce many structurally-different compounds. A method has been found to design MCRs going from libraries of compounds to libraries of reactions [180].…”
mentioning
confidence: 99%
“…Multicomponent reactions have emerged as powerful synthetic strategies because of their efficiency, atom economy, high selectivity and convenient construction of multiple new bonds. [79][80][81] These characteristics give rapid access to combinatorial libraries of complex organic molecules for efficient lead structure identification and optimization in drug discovery. [82][83][84] This section reviews three-, four and five-component reactions of isatins that have been employed in the synthesis of three-to seven membered spiro-heterocycles bearing one or more heteroatoms.…”
Section: Synthesis Involving Multicomponent Reactionsmentioning
confidence: 99%
“…[1][2][3][4][5][6] Barbituric acids play an important role in many drugs with biological and pharmaceutical properties. [7][8][9][10][11][12][13][14][15][16] They are wellknown as anticonvulsants, hypnotics, sedatives, and anxiolytic agents.…”
Section: Introductionmentioning
confidence: 99%