2018
DOI: 10.1038/s41375-018-0151-8
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Small hypoxia-primed mesenchymal stem cells attenuate graft-versus-host disease

Abstract: Mesenchymal stem cells (MSCs) are of particular interest for the treatment of immune-related diseases due to their immunosuppressive capacity. Here, we show that Small MSCs primed with Hypoxia and Calcium ions (SHC-MSCs) exhibit enhanced stemness and immunomodulatory functions for treating allogeneic conflicts. Compared with naïve cultured human umbilical cord blood-derived MSCs, SHC-MSCs were resistant to passage-dependent senescence mediated via the monocyte chemoattractant protein-1 and p53/p21 cascade and … Show more

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Cited by 78 publications
(98 citation statements)
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“…Yoo et al (31) have demonstrated that dermal papilla-like tissues produced by mesenchymal stem cells exhibited novel hair follicle-inducing activity upon transplantation in athymic mice, suggesting that human stem cells from the bone marrow or the umbilical cord may be novel and usable sources of stem cells. Our previous study demonstrated that conditioned media from hUcB-MScs contain various beneficial proteins such as growth factors and cytokines (32). In addition, as a precedent, the application of adipose tissue-derived stem cell-conditioned media containing paracrine factors has exhibited potential as a therapeutic alternative in female patients with alopecia (33).…”
Section: Discussionmentioning
confidence: 99%
“…Yoo et al (31) have demonstrated that dermal papilla-like tissues produced by mesenchymal stem cells exhibited novel hair follicle-inducing activity upon transplantation in athymic mice, suggesting that human stem cells from the bone marrow or the umbilical cord may be novel and usable sources of stem cells. Our previous study demonstrated that conditioned media from hUcB-MScs contain various beneficial proteins such as growth factors and cytokines (32). In addition, as a precedent, the application of adipose tissue-derived stem cell-conditioned media containing paracrine factors has exhibited potential as a therapeutic alternative in female patients with alopecia (33).…”
Section: Discussionmentioning
confidence: 99%
“…Immediately after the awake cystometry, the bladder tissue was harvested for histological analysis, which evaluated the epithelial denudation, mast cell infiltration, tissue fibrosis, and apoptosis with cytokeratin immunostaining (Keratin, Pan Ab-1; Thermo Scientific, Foster City, CA, USA), toluidine blue staining (Toluidine blue-O; Daejung Chemicals and Metals, Seoul, Korea), Masson's trichrome staining (Junsei Chemical, Tokyo, Japan), and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining (Roche, Mannheim, Germany), respectively [6,7,16]. Engraftment of the administered M-MSCs was determined by immunofluorescence analysis (EVOS, FL Color Imaging System, Life Technologies, Carlsbad, CA, USA) of human β2-microglobulin (hB2M) (mouse monoclonal, SC80668; Santa Cruz Biotechnology Inc., Paso Robles, CA, USA) and visualized by Alexa 488-conjugated (A11029) anti-mouse antibody (Molecular Probes, Grand Island, NY, USA), as previously described [2,9]. The nuclei were counterstained with 4 ,6 -diamino-2-phenylindole.…”
Section: Histological Examinationsmentioning
confidence: 99%
“…Stem cell therapy is considered a potential alternative treatment for chronic, degenerative disease which has limited therapeutic options with suboptimal efficacy [1][2][3]. Interstitial cystitis/bladder pain syndrome (IC/BPS), a symptomatic diagnosis characterized by chronic pelvic pain that lasts for more than six weeks and frequently accompanies lower urinary tract symptoms such as frequency and urgency in the absence of infection and other pathologies, is an ideal candidate for stem cell therapy [4][5][6][7].…”
Section: Introductionmentioning
confidence: 99%
“…These cells are thereby self-sustaining and can differentiate into progenitor cells to replace aging cells undergoing apoptosis [1,2]. This potential has rendered stem cell research a predominant area of interest in the field of regenerative medicine, which focuses on fundamental over conservative treatments [3][4][5].…”
Section: Introductionmentioning
confidence: 99%
“…The use of stem cells in medicine began with bone marrow transplantation for myeloproliferative diseases. Stem cell therapy for other disease entities, including autoimmune disease, spinal cord injury, and cardiovascular disease have also been, and continue to be, investigated [4,5,[17][18][19][20]. Bladder dysfunction is an excellent candidate for stem cell therapy due to its chronic nature and high prevalence [21,22].…”
Section: Introductionmentioning
confidence: 99%