Small interfering RNA from the lab discovery to patients' recovery

Caillaud, Marie; Madani, Mévidette El; Massaad-Massade, Liliane

doi:10.1016/j.jconrel.2020.02.032

Cited by 49 publications

(41 citation statements)

References 130 publications

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“…Kim et al [ 16 ] reported that hydrophobic quantum dots (QDs) [ 17 ] were effectively incorporated into lipid bilayers, and then therapeutic short-interfering RNAs (siRNAs) [ 18 ] were complexed with QD-lipid nanocarriers (QLs). Anti-epidermal growth factor receptor [ 19 ] (EGFR) aptamer-lipid conjugates were inserted into the QLs for triple-negative breast cancer (TNBC) targeting.…”

Section: Targeted Deliverymentioning

confidence: 99%

Recent advances in aptamer applications for analytical biochemistry

Zon

2022

Analytical Biochemistry

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Aptamers are typically defined as relatively short (20–60 nucleotides) single-stranded DNA or RNA molecules that bind with high affinity and specificity to various types of targets. Aptamers are frequently referred to as “synthetic antibodies” but are easier to obtain, less expensive to produce, and in several ways more versatile than antibodies. The beginnings of aptamers date back to 1990, and since then there has been a continual increase in aptamer publications. The intent of the present account was to focus on recent original research publications, i.e., those appearing in 2019 through April 2020, when this account was written. A Google Scholar search of this recent literature was performed for relevance-ranking of articles. New methods for selection of aptamers were not included. Nine categories of applications were organized and representative examples of each are given. Finally, an outlook is offered focusing on “faster, better, cheaper” application performance factors as key drivers for future innovations in aptamer applications.

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Section: Targeted Deliverymentioning

confidence: 99%

Recent advances in aptamer applications for analytical biochemistry

Zon

2022

Analytical Biochemistry

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“…Typically, cationic lipids, such as N -[1-(2,3-dioleyloxy)propyl]-n,n,n-trimethylammonium chloride (DOTMA) and 1,2-dioleoyl-3-trimethylammonium-propane chloride salt (DOTAP), are used to form lipoplexes with, or encapsulate, RNA [ 36 ]. The addition of neutral helper lipids, such as dioleoyl phosphatidylethanolamine (DOPE) and cholesterol, in the lipoplexes provide the ability to facilitate RNA complexation, increase stability of the lipoplexes, and reduce toxicity [ 37 , 38 ]. One major problem associated with lipid-based systems for pulmonary delivery is their poor structural stability because they readily fuse with pulmonary surfactants in the airways [ 39 ], leading to premature release of RNA before cellular uptake.…”

Section: Rna Delivery Vectors For Pulmonary Deliverymentioning

confidence: 99%

Inhaled RNA Therapy: From Promise to Reality

Chow

Qiu

Lam

2020

Trends in Pharmacological Sciences

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RNA-based medicine is receiving growing attention for its diverse roles and potential therapeutic capacity. The largest obstacle in its clinical translation remains identifying a safe and effective delivery system. Studies investigating RNA therapeutics in pulmonary diseases have rapidly expanded and drug administration by inhalation allows the direct delivery of RNA therapeutics to the target site of action while minimizing systemic exposure. In this review, we highlight recent developments in pulmonary RNA delivery systems with the use of nonviral vectors. We also discuss the major knowledge gaps that require thorough investigation and provide insights that will help advance this exciting field towards the bedside.

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“…One of the most studied and recognized sphere of CLs application is their use for transfection. Their positive charge makes them an exceptional nanocarrier for negatively charged nucleic acid sequences and is advantageous due to higher tissue uptake and endosomal escape capabilities [ 198 ]. For a few decades, cationic liposomes have attracted attention due to their lower immunogenicity, little to no toxicity, when biodegradable lipids are used, and they have since been studied thoroughly to be used in transfection [ 199 ].…”

Section: Self-assembled Amphiphilic Systems As Smart Drug Nanocarrmentioning

confidence: 99%

“…For a few decades, cationic liposomes have attracted attention due to their lower immunogenicity, little to no toxicity, when biodegradable lipids are used, and they have since been studied thoroughly to be used in transfection [ 199 ]. Thus, scientific interest in CLs for transfection has not dwindled in the past few years [ 198 , 200 , 201 , 202 , 203 , 204 ]. Another major field of CL application is their use as vaccine adjuvants due to their ability to protect the delivered vaccine, retain it at the injection site, and some degree of immunostimulation [ 205 , 206 ].…”

Section: Self-assembled Amphiphilic Systems As Smart Drug Nanocarrmentioning

confidence: 99%

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Kashapov

Gaynanova

Gabdrakhmanov

et al. 2020

IJMS

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This review focuses on synthetic and natural amphiphilic systems prepared from straight-chain and macrocyclic compounds capable of self-assembly with the formation of nanoscale aggregates of different morphology and their application as drug carriers. Since numerous biological species (lipid membrane, bacterial cell wall, mucous membrane, corneal epithelium, biopolymers, e.g., proteins, nucleic acids) bear negatively charged fragments, much attention is paid to cationic carriers providing high affinity for encapsulated drugs to targeted cells. First part of the review is devoted to self-assembling and functional properties of surfactant systems, with special attention focusing on cationic amphiphiles, including those bearing natural or cleavable fragments. Further, lipid formulations, especially liposomes, are discussed in terms of their fabrication and application for intracellular drug delivery. This section highlights several features of these carriers, including noncovalent modification of lipid formulations by cationic surfactants, pH-responsive properties, endosomal escape, etc. Third part of the review deals with nanocarriers based on macrocyclic compounds, with such important characteristics as mucoadhesive properties emphasized. In this section, different combinations of cyclodextrin platform conjugated with polymers is considered as drug delivery systems with synergetic effect that improves solubility, targeting and biocompatibility of formulations.

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Small interfering RNA from the lab discovery to patients' recovery

Cited by 49 publications

References 130 publications

Recent advances in aptamer applications for analytical biochemistry

Recent advances in aptamer applications for analytical biochemistry

Inhaled RNA Therapy: From Promise to Reality

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

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