Small intestinal bacterial overgrowth is common both among patients with alcoholic and idiopathic chronic pancreatitis

Kumar, K. Kishore; Ghoshal, Uday C; Srivastava, Deepakshi; Misra, Asha; Mohindra, Samir

doi:10.1016/j.pan.2014.05.792

Cited by 32 publications

(42 citation statements)

References 19 publications

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“…The prevalence of SIBO was reported to be 67.7% by jejuna culture [3], considered to be the gold standard in SIBO diagnosis. Although the prevalence of 47.2% considering breath H 2 and CH 4 in our study was low compared to that determined by jejunal culture, it was markedly higher compared to the prevalence of 14e40% reported in previous studies [2,4,19] evaluating only breath H 2 .…”

Section: Discussioncontrasting

confidence: 92%

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Breath hydrogen and methane are associated with intestinal symptoms in patients with chronic pancreatitis

et al. 2015

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Section: Discussioncontrasting

confidence: 92%

“…Therefore a breath test is a simple alternative and acceptable method for diagnosis of SIBO. Recently the glucose breath test was used to evaluate the SIBO in CP [2,4,15]. Only one study [1] measuring LBT has been reported in English literature.…”

Section: Discussionmentioning

confidence: 99%

Breath hydrogen and methane are associated with intestinal symptoms in patients with chronic pancreatitis

et al. 2015

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“…In the same study, there were no differences between CP patients with or without SIBO in terms of nutritional parameters. Kumar et al 22 and Signoretti et al 12 instead, found no difference between patients with or without SIBO in terms of symptoms. Signoretti et al 12 reported that Vitamin D level showed a trend close to significance for being lower in CP patients with SIBO as compared to those without SIBO (15.9 ng/ml vs 25.2 ng/ml, p ¼ 0.08).…”

Section: Study Namementioning

confidence: 95%

“…Among the nine studies included in this meta-analysis, five 12,[20][21][22]24 evaluated the differences between CP patients with or without SIBO in terms of symptoms and/or nutritional parameters. In the study by Trespi and colleagues, 20 patients with SIBO more frequently complained diarrhoea as compared to those without (73% vs 9%, p ¼ 0.001).…”

Section: Study Namementioning

confidence: 99%

Systematic review and meta‐analysis: Small intestinal bacterial overgrowth in chronic pancreatitis

et al. 2016

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Background: Evidence on small intestinal bacterial overgrowth (SIBO) in patients with chronic pancreatitis (CP) is conflicting. Aim: The purpose of this study was to perform a systematic review and meta-analysis on the prevalence of SIBO in CP and to examine the relationship of SIBO with symptoms and nutritional status. Methods: Case-control and cross-sectional studies investigating SIBO in CP patients were analysed. The prevalence of positive tests was pooled across studies, and the rate of positivity between CP cases and controls was calculated. Results: In nine studies containing 336 CP patients, the pooled prevalence of SIBO was 36% (95% confidence interval (CI) 17-60%) with considerable heterogeneity (I 2 ¼ 91%). A sensitivity analysis excluding studies employing lactulose breath test gave a pooled prevalence of 21.7% (95% CI 12.7-34.5%) with lower heterogeneity (I 2 ¼ 56%). The odds ratio for a positive test in CP vs controls was 4.1 (95% CI 1.6-10.4) (I 2 ¼ 59.7%). The relationship between symptoms and SIBO in CP patients varied across studies, and the treatment of SIBO was associated with clinical improvement. Conclusions: One-third of CP patients have SIBO, with a significantly increased risk over controls, although results are heterogeneous, and studies carry several limitations. The impact of SIBO and its treatment in CP patients deserve further investigation.

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“…Hence, abnormal gut motility, bacterial overgrowth, and changes in the intestinal milieu are well-known complications of pancreatic insufficiency. [32][33][34] However, no association between pregabalin response and pancreatic insufficiency was found.…”

Section: Supplementary Factors and Their Relation To Outcomementioning

confidence: 97%

Is Timing of Medical Therapy Related to Outcome in Painful Chronic Pancreatitis?

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et al. 2016

Pancreas

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Small intestinal bacterial overgrowth is common both among patients with alcoholic and idiopathic chronic pancreatitis

Cited by 32 publications

References 19 publications

Breath hydrogen and methane are associated with intestinal symptoms in patients with chronic pancreatitis

Breath hydrogen and methane are associated with intestinal symptoms in patients with chronic pancreatitis

Systematic review and meta‐analysis: Small intestinal bacterial overgrowth in chronic pancreatitis

Is Timing of Medical Therapy Related to Outcome in Painful Chronic Pancreatitis?

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