1999
DOI: 10.1042/cs0970633
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Small-intestinal mucosal protein synthesis and whole-body protein turnover in alcoholic liver disease

Abstract: We used stable-isotope-labelled amino acids to measure the effects of alcoholic liver disease (ALD) on whole-body protein turnover and small-intestinal mucosal protein synthesis. Groups comprising eight patients with ALD and eight healthy control subjects were studied. They received primed, continuous intravenous infusions of L-[1-(13)C]leucine after an overnight fast; after 4 h, duodenal biopsies were obtained via endoscopy. Protein synthesis was calculated from protein labelling relative to intracellular leu… Show more

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Cited by 2 publications
(1 citation statement)
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“…Our calculated S was found to be similar to the data described for healthy adults in the range of 3.0-4.0 g kg −1 day −1 [22,26]. However, only few results are available so far in the scientific literature on the effect of alcohol drinking on the protein turnover in humans [34][35][36][37]. Understandably, our findings are difficult to compare with the data of other studies since different groups of subjects, stable isotope-labelled tracer substances, methodologies, dosages, and units, respectively, were used.…”
Section: Discussionsupporting
confidence: 83%
“…Our calculated S was found to be similar to the data described for healthy adults in the range of 3.0-4.0 g kg −1 day −1 [22,26]. However, only few results are available so far in the scientific literature on the effect of alcohol drinking on the protein turnover in humans [34][35][36][37]. Understandably, our findings are difficult to compare with the data of other studies since different groups of subjects, stable isotope-labelled tracer substances, methodologies, dosages, and units, respectively, were used.…”
Section: Discussionsupporting
confidence: 83%