Small LDL-Cholesterol is Superior to LDL-Cholesterol for Determining Severe Coronary Atherosclerosis

Koba, Shinji; Yokota, Yuuya; Hirano, Tsutomu; Ito, Yasuki; Ban, Yoshiyuki; Tsunoda, Fumiyoshi; Sato, Takatoshi; Miyake, Shoji; Suzuki, Hiroshi; Geshi, Eiichi; Kobayashi, Youichi; Kubo, Takashi

doi:10.5551/jat.e572

Cited by 86 publications

(67 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Small LDL particles have been shown to be more atherogenic than LDL particles in cross-sectional [5][6][7] and prospective 23) studies. Recent use of HPLC with a gel permeation column to more precisely separate lipoproteins led to our discovery that levels of very small LDL particles were associated with circulating malondialdehyde-modified (MDA)-LDL levels, an oxidized form of LDL 24) .…”

Section: Discussionmentioning

confidence: 99%

“…For example, the abundance of small low-density lipoprotein (LDL) particles is reported to reflect the atherogenic lipoprotein profile and is superior to other measures of atherogenic dyslipidemia such as high levels of LDL cholesterol and low levels of high-density lipoprotein (HDL) cholesterol for predicting atherosclerotic disease [5][6][7] . Recently, high-performance liquid chromatography (HPLC) using a gel permeation column has been established as an alternative to nuclear magnetic resonance (NMR) spectroscopy 8) for classifying and quantifying lipoproteins on the basis of differences in particle size 9) .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Very Small Low-Density Lipoprotein Cholesterol Level is a Determinant of Arterial Stiffness in Men with Impaired Glucose Metabolism

Takahashi¹,

Imamura

Yoshikane³

et al. 2010

JAT

View full text Add to dashboard Cite

Aim:Pulse wave velocity (PWV), an estimate of arterial stiffness, is an important predictor of cardiovascular risk. The aim of this study was to investigate the relationship between lipoprotein subclasses and brachial-ankle PWV (baPWV). Methods: A total of 131 apparently healthy Japanese men without a history of cardiovascular disease were divided into two groups: normal glucose metabolism (n 87) and impaired glucose metabolism (n 44). Cholesterol concentrations of major lipoproteins and their subclasses were determined by HPLC with gel permeation columns. Results: In the normal glucose metabolism group, age, systolic blood pressure, and diastolic pressure were associated with increased baPWV, and a stepwise multiple linear regression analysis revealed that age (p 0.022) and systolic blood pressure (p 0.001) were significantly independent determinants of baPWV. In the impaired glucose metabolism group, age (p 0.002), very small LDL cholesterol (p 0.012), systolic blood pressure (p 0.021), and the fasting plasma glucose concentration (p 0.038) were identified as independent determinants of baPWV, although a univariate analysis revealed significant relationships of several plasma lipid compositions or species to baPWV. Conclusions: In addition to aging, hypertension and glucose levels, very small LDL cholesterol levels appear to play an important role in the development of arterial stiffness in men with impaired glucose metabolism.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Very Small Low-Density Lipoprotein Cholesterol Level is a Determinant of Arterial Stiffness in Men with Impaired Glucose Metabolism

Takahashi¹,

Imamura

Yoshikane³

et al. 2010

JAT

View full text Add to dashboard Cite

show abstract

“…Установлено, что повышенный риск КБС, свя-занной с атеросклерозом, сопряжен с наличием в крови субфракций мелких плотных частиц ЛПНП 3-7 [6,[8][9][10]; концентрация мелких плотных частиц ЛПНП 3-7 коррелирует с развитием КБС [11], инфаркта миокарда [12], инсульта и других БСК [13,14]. Также в ряде исследований последних лет пока-зана независимая связь субфракций ЛПНП не только с КБС, но и с цереброваскулярными заболеваниями [7].…”

Section: Specifics Of Subfractional Spectrum Of Apolipoprotein B Relaunclassified

“…В работе Calvet D, et al [15], как и в работе оте-чественных авторов [16], показана высокая частота развития коронарного атеросклероза у пациентов с клиникой цереброваскулярных заболеваний. По данным проспективных и рандомизированных исследований, корреляция между содержанием мел-ких плотных частиц ЛПНП и риском КБС носит более выраженный характер, чем связь между забо-леванием и уровнем ХС ЛПНП и крупных частиц ЛПНП 1 [10,[17][18][19].…”

Section: Specifics Of Subfractional Spectrum Of Apolipoprotein B Relaunclassified

Specifics of Subfractional Spectrum of Apolipoprotein B Related Lipoproteines in Carotid or Coronary Atherosclerosis Patients

Гаврилова¹,

Метельская²,

Ozerova³

et al. 2016

Russ J Cardiol

View full text Add to dashboard Cite

“…The Adult Treatment Panel (ATP) III has defi ned emerging risk factors for CAD, including small, dense low-density lipoprotein (LDLs) (11). LDLs particles are present in families with premature CAD and hyperapobetalipoproteinemia, familial combined hyperlipidemia, familial dyslipidemic hypertension, and metabolic syndrome (12)(13)(14)(15)(16)(17). Small, dense LDLs are often accompanied by increased triglycerides (TGs) and low high-density lipoproteins (HDL) (18).…”

mentioning

confidence: 99%

Low density lipoprotein size in relation to carotid intima-media thickness in coronary artery disease

Alabakovska¹,

Tosheska²,

Спироски³

et al. 2012

BLL

View full text Add to dashboard Cite

Abstract:Objective: With increasing interest in the role of non-traditional lipid risk factors in coronary artery disease, we undertook this study to relate LDL subclass size and carotid intima-media thickness of the common carotid artery in coronary artery disease patients. Methods: The study was conducted in 106 patients during their fi rst visit (study group I) and after 12 months (study group II). Intima-media thickness of the common carotid artery was determined using B-mode ultrasound. Separation of LDL subclasses was preformed by 3-31 % polyacrylamide gradient gel electrophoresis. Results: LDL 3 was the dominant subclass in both study groups, but there was statistically signifi cant difference in the distribution of dominant LDL subclasses (p<0.01). The mean carotid intima-media thickness was significantly increased (p<0.001) in coronary artery disease patients after 12 months period. There was signifi cant negative correlation between intima-media thickness and LDL size in both study groups (p<0.05). Intima-media thickness was not signifi cantly correlated with plasma lipid concentrations. Multiple regression analyses show that strongest independent predictor of the intima-media thickness variation was diastolic blood pressure, followed by LDL size and age, and accounted for 29 % of the observed variability in intima-media thickness. Conclusion: LDL particle size is independently associated with carotid intima-media thickness in coronary artery disease patients with normal levels of traditional lipid risk. These results imply that small, dense LDL subclasses are an important indicator for assessing atherosclerosis and its progression (Tab. 4, Ref. 39). Full Text in PDF www.elis.sk.

show abstract

Small LDL-Cholesterol is Superior to LDL-Cholesterol for Determining Severe Coronary Atherosclerosis

Abstract: sd-LDL-C levels are more powerful than LDL-C levels for the determination of severe stable CHD.

Cited by 86 publications

References 37 publications

Very Small Low-Density Lipoprotein Cholesterol Level is a Determinant of Arterial Stiffness in Men with Impaired Glucose Metabolism

Very Small Low-Density Lipoprotein Cholesterol Level is a Determinant of Arterial Stiffness in Men with Impaired Glucose Metabolism

Specifics of Subfractional Spectrum of Apolipoprotein B Related Lipoproteines in Carotid or Coronary Atherosclerosis Patients

Low density lipoprotein size in relation to carotid intima-media thickness in coronary artery disease

Contact Info

Product

Resources

About