2011
DOI: 10.1681/asn.2010050570
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Small Leucine-Rich Proteoglycans in Kidney Disease

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Cited by 70 publications
(107 citation statements)
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“…Upon tissue stress or injury, matrix components will be released and turn into signaling molecules. 12,18,19 Among this large group of ECM components, only a few, such as biglycan, 14 decorin, 16 hyaluronan, 20 versican, 21 tenascin-C, 22 fibrinogen and heparan sulfate fragments, 23 are capable of interacting with PRRs, thereby alerting the innate immune system to impending tissue damage. These mechanisms give rise to a rapid response reaction without the need for de novo synthesis of danger molecules.…”
Section: Intracellular and Extracellular Dampsmentioning
confidence: 99%
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“…Upon tissue stress or injury, matrix components will be released and turn into signaling molecules. 12,18,19 Among this large group of ECM components, only a few, such as biglycan, 14 decorin, 16 hyaluronan, 20 versican, 21 tenascin-C, 22 fibrinogen and heparan sulfate fragments, 23 are capable of interacting with PRRs, thereby alerting the innate immune system to impending tissue damage. These mechanisms give rise to a rapid response reaction without the need for de novo synthesis of danger molecules.…”
Section: Intracellular and Extracellular Dampsmentioning
confidence: 99%
“…The finding that decorin, besides being a structural matrix component, acts as a signaling molecule gave rise to a new paradigm of how SLRPs regulate a host of biologic processes, such as differentiation, proliferation, migration and apoptosis. Decorin is capable of binding to four different receptor tyrosine kinases (RTKs), including the epidermal growth factor receptor (EGFR), 34 insulin-like growth factor-1 receptor (IGF-IR), [35][36][37][38] Met 39 and vascular endothelial growth factor receptor 2 (VEGFR2), 40 thereby impacting on fibrogenesis, 19 tumor growth and metastatic spreading. 12,41,42 A summary of recent data demonstrating the intricacy of decorin signaling, which links innate immunity, inflammation and tumor growth 16 is provided below.…”
Section: The Family Of Small Leucine-rich Proteoglycansmentioning
confidence: 99%
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“…DAMPs comprise endogenous molecules that are released following tissue injury and signal the innate immune system to initiate and maintain inflammatory responses (14)(15)(16). DAMPs are normally sequestered intracellularly or are bound tightly in the ECM and can only become active signaling molecules following release after cell damage or ECM degradation.…”
Section: Introductionmentioning
confidence: 99%