Small low-density lipoproteins and vascular cell adhesion molecule-1 are increased in association with hyperlipidemia in preeclampsia

Hubel, Carl A.; Lyall, Fiona; Weissfeld, Lisa A.; Gandley, Robin E.; Roberts, James M.

doi:10.1016/s0026-0495(98)90337-7

Cited by 139 publications

(113 citation statements)

References 47 publications

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“…These findings are similar to Sattar et al (9). However others have found significant increase in serum TC in toxaemia of pregnancy (5,12). Though in our own study, the mean value of HDL-C was about 30% higher in the third trimester of normal pregnancy over the nonpregnant women, but statistically the alteration was not significant (P>0.05).…”

Section: Resultssupporting

confidence: 89%

“…A significant fall in LDL-C level in third trimester of normal pregnancy as observed in present study may be attributed to hyperestrogenaemia, while LDL-C level increases significantly in PIH. A significantly higher level of beta-lipoprotein was also reported by many workers in third trimester of gestational proteinuric hypertension (12,19,20). Some scientists observed significantly higher mean titre of autoantibodies to MDA-LDL, the IgG antibodies to an epitope of oxidized LDL, in preeclamptic patients, as enhanced lipid peroxidation is involved in the foam cell formation of decidua in the pathogenesis of toxaemia of pregnancy (20,21).…”

Section: Resultsmentioning

confidence: 56%

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Study of serum lipid profile in pregnancy induced hypertension

Mukhopadhyay

Saha

2006

Indian J Clin Biochem

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 56%

Study of serum lipid profile in pregnancy induced hypertension

Mukhopadhyay

Saha

2006

Indian J Clin Biochem

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“…These include a dyslipidemia with elevated triglycerides, free fatty acids, and LDL cholesterol, and reduced HDL cholesterol, 31 with an increased prevalence of low dense LDL. 32 Insulin resistance 33,34 and uric acid, other components of the metabolic syndrome, are also increased in preeclampsia. 22 Many of these changes, including elevated free fatty acids 35 and uric acid, 36 can be demonstrated from very early pregnancy.…”

Section: Pathological and Pathophysiological Changesmentioning

confidence: 99%

Preeclampsia

2005

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Abstract-Preeclampsia is a pregnancy complication with serious consequences for mother and infant. The disorder is diagnosed by gestational hypertension and proteinuria but is far more than pregnancy induced hypertension. Preeclampsia is proposed to occur in 2 stages. Key Words: preeclampsia Ⅲ hypertension, pregnancy Ⅲ oxidative stress Ⅲ endothelium P reeclampsia is a pregnancy complication recognized by new-onset gestational hypertension and proteinuria (see definitions below). The disorder affects both mothers and their infants. Once the disease is evident clinically, it can be cured only by delivery. In developed countries, surveillance for preeclampsia through prenatal care allows for early identification and intervention via delivery. This management has changed little in the last 100 years, and it is very effective at reducing maternal mortality. However, maternal morbidity remains great with preeclampsia, which continues to be one of the leading causes for the admission of pregnant women to intensive care units in the developed world. 1 Furthermore, fetal mortality and morbidity is considerable, related to the effects of the disease on the fetus as well as prematurity. The indicated delivery of women to prevent the progression of preeclampsia is responsible for 15% of all preterm births. 2 In developing countries, where inadequate prenatal care limits preeclampsia surveillance, maternal mortality is common, accounting for 50 000 deaths yearly. 3 The hypertensive disorders of pregnancy include hypertension that antedates pregnancy, chronic hypertension, and gestational hypertension occurring uniquely during pregnancy. When the gestational hypertension is accompanied by new-onset proteinuria, the disorder is termed preeclampsia, and when not associated with proteinuria, transient hypertension of pregnancy. If the woman with chronic hypertension also manifests evidence of preeclampsia, this is classified chronic hypertension with superimposed preeclampsia. Eclampsia is the occurrence of seizures in women with preeclampsia. 4 These criteria have been extraordinarily useful to aid in recognizing pregnant women at risk. Greatest risk for mother and baby is present with preeclampsia, and the risk for chronic hypertensive pregnancy is primarily with superimposed preeclampsia. However, the attention to hypertension has, for many years, limited research attention to primarily mechanisms of hypertension. This has not been helpful. In the last 2 decades, appreciation that preeclampsia is a multisystemic syndrome characterized by vasoconstriction, metabolic changes, endothelial dysfunction, activation of the coagulation cascade, and increased inflammatory response, to mention only some of the organ systems involved, has redirected research. 5 As a result, progress in understanding the disorder has accelerated greatly, with attendant optimism for potentially effective treatments. 5 In this article, we consider this recent progress and its clinical implications.

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“…66 Many of the risk factors that predispose to the functional endothelial alterations of atherosclerosis also come into play in PE. Elevated homocysteine, 67 elevated triglycerides 68 with associated small dense low-density lipoprotein (LDL), 69 and insulin resistance 70 are all associated with increased risk for both disorders. Some of these changes such as elevated homocysteine persist beyond pregnancy, yet the PE syndrome and the attendant endothelial dysfunction abate with delivery.…”

Section: Effects On Ex Vivo Vesselsmentioning

confidence: 99%

Hypertension in pregnancy

Pipkin

Roberts

2000

J Hum Hypertens

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Hypertension arising during pregnancy remains one of the two most frequently-cited causes of maternal death in the UK. In some cases, pregnancy is unmasking underlying hypertension, which manifests itself in later life. Pregnant women who develop de novo proteinuric hypertension (pre-eclampsia, PE) can share many risk factors with patients with the metabolic syndrome, such as obesity, dyslipidaemia and insulin resistance. However, more than half the women who develop PE remain normotensive thereafter. There is a genetic component(s) to the disease, but it is most improbable that there is a 'PE gene'. Rather, there are factors such as geneticallydetermined thrombophilias which are predisposers but not prerequisites. Impaired placentation is a feature, with inadequate invasion of the spiral arteries by syncytiotrophoblast and poor remodelling. However, similiar features are found in association with non-hypertensive

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Small low-density lipoproteins and vascular cell adhesion molecule-1 are increased in association with hyperlipidemia in preeclampsia

Cited by 139 publications

References 47 publications

Study of serum lipid profile in pregnancy induced hypertension

Study of serum lipid profile in pregnancy induced hypertension

Preeclampsia

Hypertension in pregnancy

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