2024
DOI: 10.1128/mmbr.00097-23
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Small molecule communication of Legionella : the ins and outs of autoinducer and nitric oxide signaling

Sarah Michaelis,
Laura Gomez-Valero,
Tong Chen
et al.

Abstract: SUMMARY Legionella pneumophila is a Gram-negative environmental bacterium, which survives in planktonic form, colonizes biofilms, and infects protozoa. Upon inhalation of Legionella -contaminated aerosols, the opportunistic pathogen replicates within and destroys alveolar macrophages, thereby causing a severe pneumonia termed Legionnaires’ disease. Gram-negative bacteria employ low molecular weight organic compounds as well as the inorganic gas nitric … Show more

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