2016
DOI: 10.1016/j.ejmech.2016.01.061
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Small molecule glycoconjugates with anticancer activity

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Cited by 32 publications
(14 citation statements)
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“…This can also be associated with interactions with transition metals such as iron, copper and nickel, which can form complexes with quinolines, 8-hydroxyquinolines and thiosemicarbazone derivatives [ 80 83 ]. Additionally, in previous studies, we indicated that the antiproliferative activity of quinoline-related compounds may be associated with the ability to intercalate into DNA, leading to the p53-independent mechanism of action of these compounds [ 49 , 84 ]. Moreover, many iron chelators have been reported to be topoisomerase inhibitors or poisons [ 85 ].…”
Section: Discussionmentioning
confidence: 99%
“…This can also be associated with interactions with transition metals such as iron, copper and nickel, which can form complexes with quinolines, 8-hydroxyquinolines and thiosemicarbazone derivatives [ 80 83 ]. Additionally, in previous studies, we indicated that the antiproliferative activity of quinoline-related compounds may be associated with the ability to intercalate into DNA, leading to the p53-independent mechanism of action of these compounds [ 49 , 84 ]. Moreover, many iron chelators have been reported to be topoisomerase inhibitors or poisons [ 85 ].…”
Section: Discussionmentioning
confidence: 99%
“…A second group of structural components of glycoconjugates included 4-aminophenyl β- d -1-thioglycosides 5 , 6 . A simple and efficient synthesis of per- O -acetylated 4-aminophenyl β- d -1-thioglycosides 5 and 6 by reduction of a nitro group in an aglycon of corresponding 4-nitrophenyl β- d -1-thioglycosides was described recently [ 33 ].…”
Section: Resultsmentioning
confidence: 99%
“…Melting-point measurements were performed on a Stanford Research Systems OptiMelt (MPA 100). Succinic acid mono-2′,3′- O -isopropylidene-uridin-5′yl ester 1 [ 27 ], 2′,3′-di- O - tert -butyldimethylsilyluridine 2a [ 32 ], 2′,3′- O -isopropylideneuridine-5′-carboxylic acid 3 [ 31 ], 2′,3′- O -di- O - tert -butyldimethylsilyluridine-5′-carboxylic acid 4 [ 28 ], 4-aminophenyl 2,3,4,6-tetra- O -acetyl-1-thio-β- d -glucopyranoside 5 , 4-aminophenyl 2,3,4,6-tetra- O -acetyl-1-thio-β- d -galactopyranoside 6 [ 33 ], and DMTMM [ 46 ] were prepared according to the respective published procedures.…”
Section: Methodsmentioning
confidence: 99%
“…Given our strong experience in quinoline derivatives with antifungal [ 57 , 58 ], antimicrobial [ 59 , 60 , 61 , 62 ] and antiretroviral [ 63 , 64 , 65 ] activity, we decided to pursue our interest in quinolines targeting p53 deficient cells in the search for novel anticancer agents. Quinoline [ 66 , 67 , 68 , 69 , 70 , 71 ] and quinazoline [ 72 ] derivatives synthesized in our group showed strong anticancer activity. Novel compounds designed in this study appeared to be several times more effective against p53 −/− than normal cells.…”
Section: Targeting Oncogenic Mutant Tp53—one Step Aheadmentioning
confidence: 99%