2021
DOI: 10.1021/acschemneuro.1c00524
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Small Molecule Improvement of Trafficking Defects in Models of Neurodegeneration

Abstract: Disrupted cellular trafficking and transport processes are hallmarks of many neurodegenerative disorders (NDs). Recently, efforts have been made toward developing and implementing experimental platforms to identify small molecules that may help restore normative trafficking functions. There have been a number of successes in targeting endomembrane trafficking with the identification of compounds that restore cell viability through rescue of protein transport and trafficking. Here, we describe some of the exper… Show more

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