Small molecule inhibitors of mammalian glycosylation

Simple, Economic, and Robust Rail-Based Setup for Super-Resolution Localization Microscopy

“…To further evaluate the performance of the setup using a more challenging sample, we imaged the glycocalyx: a complex meshwork of cell-surface glycans that are vital for various cellular processes ( Figure 3 C). 51 Until recently, imaging the glycocalyx with high spatial resolution remained a challenging task owing to the lack of appropriate tools to specifically label the glycocalyx and due to its height, which is below the diffraction limit. Here, we combine metabolic labeling of sialic acid residues with super-resolution microscopy as described earlier.…”

The glycocalyx: Pathobiology and repair

“…Therapeutic strategies to protect and restore the glycocalyx and its downstream functions are also highlighted in several of the manuscripts included in this special issue. In the review by Almahayni et al, a comprehensive overview of small molecule inhibitors of glycosylation is presented [14] . Although many of these inhibitors currently have limitations and exhibit cytotoxic effects, it may in the future be possible to use these inhibitors strategically to diminish the impact of aberrant glycosylation within the glycocalyx that can occur during disease progression.…”

Unraveling the Post-Translational Modifications and therapeutical approach in NSCLC pathogenesis

“…Another inhibitor is SGN-2FF which is fucosylation inhibitor but the clinical trial with these has been terminated due to adverse effects (ClinicalTrials.gov Identifier: NCT02952989). Further review article includes sialidase inhibitor, Sialyltransferase inhibitor, Fucosylation inhibitor on lung cancer cell lines [119] .…”