Small-molecule inhibitors targeting apoptosis signal-regulated kinase 1

Discovery of benzoheterocyclic-substituted amide derivatives as apoptosis signal-regulating kinase 1 (ASK1) inhibitors

“…15 Additionally, there are several other ASK1 inhibitors that will undergo clinical studies for various therapeutic areas, including inflammation, neuroprotection, amyotrophic lateral sclerosis (ALS), and acetaminophen (APAP) hepatotoxicity. 14 Selonsertib was chosen as the lead compound in this study to explore small molecule ASK1 inhibitors with different structural types, considering ASK1 as an important and promising therapeutic drug target and Selonsertib as the only clinical ASK1 inhibitor. This may facilitate further investigation into the potential benefits of ASK1 inhibition in various diseases.…”

“…However, animal models and human clinical trials have shown that combination therapy is superior to monotherapy. 14 Furthermore, a recent study has shown the potential therapeutic use of Selonsertib as a pan-antiviral drug in humans. 15 Additionally, there are several other ASK1 inhibitors that will undergo clinical studies for various therapeutic areas, including inflammation, neuroprotection, amyotrophic lateral sclerosis (ALS), and acetaminophen (APAP) hepatotoxicity.…”

“…15 Additionally, there are several other ASK1 inhibitors that will undergo clinical studies for various therapeutic areas, including inflammation, neuroprotection, amyotrophic lateral sclerosis (ALS), and acetaminophen (APAP) hepatotoxicity. 14…”

The Function of ASK1 in Sepsis and Stress-Induced Disorders

“…The above examples highlight the ASK1-p38 signaling axis and its importance to the cell stress response. Recent reviews summarize the role of ASK1 in nucleated cells [ 15 , 16 ]. We demonstrated that Ask1 is expressed in platelets even though platelets lack a nucleus and ASK1 regulates platelet signaling in response to a variety of physiological agonists [ 17 , 18 , 19 ].…”