2024
DOI: 10.1002/cbdv.202301610
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Small Molecule SHP2 Inhibitor LXQ‐217 Affects Lung Cancer Cell Proliferation in Vitro and in Vivo

Hao Sun,
Xiaoyi Bai,
Yiting Zhang
et al.

Abstract: Background SHP2 is highly expressed in a variety of cancer and has emerged as a potential target for cancer therapeutic agents. The identification of uncharged pTyr mimics is an important direction for the development of SHP2 inhibitors. Methods SPR  and CETSA were employed to verify the direct binding of LXQ‐217 to SHP2. The inhibitory effect of LXQ‐217 was characterized by linear Weaver‐Burke enzyme kinetic analysis and BIOVIA Discovery Studio. The inhibition of tumor cell proliferation by LXQ‐217 was charac… Show more

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