Small Nettle: Evaluation of Its Anxiolytic Effect in the Elevated Plus-Maze and Open Field

Doukkali, Zouhra

doi:10.21767/2386-5180.100068

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…in this study was non-sedating ( Supplementary Figure 3 ) and determined by the observed increase in beta activity ( Supplementary Figure 2 ). This setting dose of each drug is based on previous reports ( Brot et al, 1997 ; Doukkali et al, 2016 ; Shahnouri et al, 2016 ; Holmberg et al, 2018 ; Dornellas et al, 2020 ; Antonoudiou et al, 2022 ; Choudhary et al, 2022 ). Before a direct comparison study between these agents, we first investigated whether the SIT was suitable for evaluating antidepressant-like effects by administering escitalopram, a selective serotonin reuptake inhibitor (SSRI) antidepressant, to mice to examine whether it improved their social interaction.…”

Section: Resultsmentioning

confidence: 99%

Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

Takasu,

Yawata,

Tashima

et al. 2024

Front. Cell. Neurosci.

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The rapid relief of depressive symptoms is a major medical requirement for effective treatments for major depressive disorder (MDD). A decrease in neuroactive steroids contributes to the pathophysiological mechanisms associated with the neurological symptoms of MDD. Zuranolone (SAGE-217), a neuroactive steroid that acts as a positive allosteric modulator of synaptic and extrasynaptic δ-subunit-containing GABAA receptors, has shown rapid-onset, clinically effective antidepressant action in patients with MDD or postpartum depression (PPD). Benzodiazepines, on the other hand, act as positive allosteric modulators of synaptic GABAA receptors but are not approved for the treatment of patients with MDD. It remains unclear how differences in molecular mechanisms contribute to the alleviation of depressive symptoms and the regulation of associated neuronal activity. Focusing on the antidepressant-like effects and neuronal activity of the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC), we conducted a head-to-head comparison study of the neuroactive steroid allopregnanolone and the benzodiazepine diazepam using a mouse social defeat stress (SDS) model. Allopregnanolone but not diazepam exhibited antidepressant-like effects in a social interaction test in SDS mice. This antidepressant-like effect of allopregnanolone was abolished in extrasynaptic GABAA receptor δ-subunit knockout mice (δko mice) subjected to the same SDS protocol. Regarding the neurophysiological mechanism associated with these antidepressant-like effects, allopregnanolone but not diazepam increased theta oscillation in the BLA of SDS mice. This increase did not occur in δko mice. Consistent with this, allopregnanolone potentiated tonic inhibition in BLA interneurons via δ-subunit-containing extrasynaptic GABAA receptors. Theta oscillation in the mPFC of SDS mice was also increased by allopregnanolone but not by diazepam. Finally, allopregnanolone but not diazepam increased frontal theta activity in electroencephalography recordings in naïve and SDS mice. Neuronal network alterations associated with MDD showed decreased frontal theta and beta activity in depressed SDS mice. These results demonstrated that, unlike benzodiazepines, neuroactive steroids increased theta oscillation in the BLA and mPFC through the activation of δ-subunit-containing GABAA receptors, and this change was associated with antidepressant-like effects in the SDS model. Our findings support the notion that the distinctive mechanism of neuroactive steroids may contribute to the rapid antidepressant effects in MDD.

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Section: Resultsmentioning

confidence: 99%

Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

Takasu,

Yawata,

Tashima

et al. 2024

Front. Cell. Neurosci.

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“…Elevated Plus Maze (EPM) model [22][23][24][25][26] The Actophotometer test [27][28][29][30][31] The locomotor activity can be easily studied with the help of actophotometer, the rats were …”

Section: Screening For Antianxiety Activitymentioning

confidence: 99%

Antidepressant and Anxiolytic Effects of Alcoholic Extract From Tephrosia Pumila (L.) Pers

Murthy¹

2017

WJPR

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Tephrosia pumila (L.) Pers (Leguminosae (Fabaceae)), is an herbaceous climber that has been generally utilized in Indian traditional medicine for the treatment of different central nervous system (CNS) disorders. Nevertheless, the available scientific information about this species is rare and there are no reports identified with its conceivable impact on the CNS. In this work, the effects of ethanolic extract of Tephrosia pumila (L.) Pers (TPP) were assessed in rats utilizing behavioral tests sensitive to clinically effective antidepressant and anxiolytic effects compounds. The extract (200 and 400mg/kg), administered intraperitoneally, was able to decrease the immobility time of rats dose-dependently when subjected to both tail suspension and forced swim tests for antidepressant activity and elevated Pluse maze test, actophotometer test for anxiolytic effect and the effects are comparable to that of standard drugs i.e., Diazepam (20mg/kg). Neither the extracts of TPP and Diazepam, at the doses tested, produced significant effects on locomotor activity when subjected to open field behavioral test. These results demonstrated that TPP had specifically antidepressant effects in vivo. In conclusion, the present study recommended that TPP extracts possessed potential antidepressant and anxiolytic effects which could be of therapeutic interest for using in the treatment of patients with depressive disorders.

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Small Nettle: Evaluation of Its Anxiolytic Effect in the Elevated Plus-Maze and Open Field

Cited by 2 publications

References 17 publications

Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

Antidepressant and Anxiolytic Effects of Alcoholic Extract From Tephrosia Pumila (L.) Pers

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