Small nodular hepatocellular carcinoma treated by laser thermal ablation in high risk locations: preliminary results

Caspani, B.; Ierardi, Anna Maria; Motta, Fábio; Cecconi, Pietro; Fesce, E; Belli, Luca

doi:10.1007/s00330-010-1766-y

Cited by 14 publications

(16 citation statements)

References 26 publications

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“…Thermal ablation involves application of energy at the tumor site causing heating in the tissue, thereby resulting in coagulative necrosis of the tumor. Common thermal ablation methods include radiofrequency ablation (RFA), ultrasound ablation, laser ablation, and microwave ablation (Murakami et al, 1995; Rhim and Dodd, 1999; Kennedy et al, 2004; Caspani et al, 2010). RFA has been shown to be effective for the treatment of unresectable liver tumors clinically (Curley et al, 1999; Solbiati et al, 2001; Tateishi et al, 2005), offering several advantages over surgical resection, such as reduced morbidity, costs, and hospital stays (Livraghi et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

In Vivo Thermal Ablation Monitoring Using Ultrasound Echo Decorrelation Imaging

Subramanian

Rudich

Alqadah

et al. 2014

Ultrasound in Medicine & Biology

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Previous work has shown ultrasound echo decorrelation imaging can track and quantify changes in echo signals to predict thermal damage during in vitro radiofrequency ablation (RFA). In the in vivo studies reported here, the feasibility of using echo decorrelation imaging as a treatment monitoring tool is assessed. RFA was performed on a normal swine liver (N = 5) and ultrasound ablation using image-ablate arrays was performed on a rabbit liver implanted with VX2 tumors (N = 2). Echo decorrelation and integrated backscatter were computed from Hilbert transformed pulse-echo data acquired during RFA and ultrasound ablation treatments. Receiver operating characteristic (ROC) curves were employed to assess the ability of echo decorrelation imaging and integrated backscatter to predict ablation. Area under the ROC curves (AUROC) was determined for RFA and ultrasound ablation using echo decorrelation imaging. Ablation was predicted more accurately using echo decorrelation imaging (AUROC 0.832 and 0.776 for RFA and ultrasound ablation respectively) than using integrated backscatter (AUROC 0.734 and 0.494).

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Section: Introductionmentioning

confidence: 99%

In Vivo Thermal Ablation Monitoring Using Ultrasound Echo Decorrelation Imaging

Subramanian

Rudich

Alqadah

et al. 2014

Ultrasound in Medicine & Biology

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“…Caspani et al [35], who compared laser ablation results in a small series of patients with and control subjects without nodules at high-risk locations, recently reported similar results in terms of laser ablation safety irrespective of HCC nodule location.…”

Section: Francica Et Almentioning

confidence: 81%

Effectiveness, Safety, and Local Progression After Percutaneous Laser Ablation for Hepatocellular Carcinoma Nodules up to 4 cm Are Not Affected by Tumor Location

Francica¹,

Petrolati

Stasio

et al. 2012

American Journal of Roentgenology

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“…[18][19][20] Such detailed contouring is highly important in thermal ablation procedures of tumors in problematic locations and in proximity to valuable and sensitive organs. [21][22][23][24] While two-dimensional (2D) contouring of the ablation in key transaxial cross sections around the MW antenna may provide valuable clinical information, the ablation is naturally three-dimensional (3D) in nature and may have irregular geometry. Thus, a 3D display of the ablated tissue may be more informative for the clinician.…”

Section: Introductionmentioning

confidence: 99%

In vivo noninvasive three‐dimensional (3D) assessment of microwave thermal ablation zone using non‐contrast‐enhanced x‐ray CT

et al. 2020

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Purpose: To develop an image processing methodology for noninvasive three-dimensional (3D) quantification of microwave thermal ablation zones in vivo using x-ray computed tomography (CT) imaging without injection of a contrast enhancing material. Methods: Six microwave (MW) thermal ablation procedures were performed in three pigs. The ablations were performed with a constant heating duration of 8 min and power level of 30 W. During the procedure images from sixty 1 mm thick slices were acquired every 30 s. At the end of all ablation procedures for each pig, a contrast-enhanced scan was acquired for reference. Special algorithms for addressing challenges stemming from the 3D in vivo setup and processing the acquired images were prepared. The algorithms first rearranged the data to account for the oblique needle orientation and for breathing motion. Then, the gray level variance changes were analyzed, and optical flow analysis was applied to the treated volume in order to obtain the ablation contours and reconstruct the ablation zone in 3D. The analysis also included a special correction algorithm for eliminating artifacts caused by proximal major blood vessels and blood flow. Finally, 3D reference reconstructions from the contrast-enhanced scan were obtained for quantitative comparison. Results: For four ablations located >3 mm from a large blood vessel, the mean dice similarity coefficient (DSC) and the mean absolute radial discrepancy between the contours obtained from the reference contrast-enhanced images and the contours produced by the algorithm were 0.82 AE 0.03 and 1.92 AE 1.47 mm, respectively. In two cases of ablation adjacent to large blood vessels, the average DSC and discrepancy were: 0.67 AE 0.6 and 2.96 AE 2.15 mm, respectively. The addition of the special correction algorithm utilizing blood vessels mapping improved the mean DSC and the mean absolute discrepancy to 0.85 AE 0.02 and 1.19 AE 1.00 mm, respectively. Conclusions: The developed algorithms provide highly accurate detailed contours in vivo (average error < 2.5 mm) and cope well with the challenges listed above. Clinical implementation of the developed methodology could potentially provide real time noninvasive 3D accurate monitoring of MW thermal ablation in-vivo, provided that the radiation dose can be reduced.

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Small nodular hepatocellular carcinoma treated by laser thermal ablation in high risk locations: preliminary results

Abstract: LTA can be considered a safe treatment in "critical nodules".

Cited by 14 publications

References 26 publications

In Vivo Thermal Ablation Monitoring Using Ultrasound Echo Decorrelation Imaging

In Vivo Thermal Ablation Monitoring Using Ultrasound Echo Decorrelation Imaging

Effectiveness, Safety, and Local Progression After Percutaneous Laser Ablation for Hepatocellular Carcinoma Nodules up to 4 cm Are Not Affected by Tumor Location

In vivo noninvasive three‐dimensional (3D) assessment of microwave thermal ablation zone using non‐contrast‐enhanced x‐ray CT

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