2018
DOI: 10.3389/fgene.2018.00230
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Small Non-coding RNA Expression and Vertebrate Anoxia Tolerance

Abstract: Background: Extreme anoxia tolerance requires a metabolic depression whose modulation could involve small non-coding RNAs (small ncRNAs), which are specific, rapid, and reversible regulators of gene expression. A previous study of small ncRNA expression in embryos of the annual killifish Austrofundulus limnaeus, the most anoxia-tolerant vertebrate known, revealed a specific expression pattern of small ncRNAs that could play important roles in anoxia tolerance. Here, we conduct a comparative study on the presen… Show more

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Cited by 34 publications
(37 citation statements)
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“…are not yet well characterized in most taxa. Although it is relatively straightforward to identify non-coding RNAs, their functions in non-model organisms largely remain to be determined (101). Interestingly, expression of RNA-editing ADAR proteins have been observed in stress-resistant post-diapause embryos of Artemia (26), suggesting that embryonic physiological diversity may be greater than would be predicted based on the genomic complement of potential RNA molecules, further highlighting the need to study plasticity across development to develop a holistic understanding of responses to climate change (14).…”
Section: Adjustment (Physiology)mentioning
confidence: 99%
“…are not yet well characterized in most taxa. Although it is relatively straightforward to identify non-coding RNAs, their functions in non-model organisms largely remain to be determined (101). Interestingly, expression of RNA-editing ADAR proteins have been observed in stress-resistant post-diapause embryos of Artemia (26), suggesting that embryonic physiological diversity may be greater than would be predicted based on the genomic complement of potential RNA molecules, further highlighting the need to study plasticity across development to develop a holistic understanding of responses to climate change (14).…”
Section: Adjustment (Physiology)mentioning
confidence: 99%
“…For example, differential miRNA profiles in the highland yak compared to the lowland cow are enriched for hypoxia signaling pathways in the respiratory and cardiovascular systemsa key component of altitude adaptation [20]. These small non-coding RNAs also regulate seasonal phenotypic shifts, including metabolic depression that accompanies hibernation, anoxia tolerance and estivation in several vertebrates, although the exact miRNAs that may regulate these transitions appear speciesspecific [21,22]. MiRNAs are also implicated in protection against environmental stresses such as hypoxia, extreme temperature and nutrient limitation in animals and plants [23][24][25].…”
Section: Introductionmentioning
confidence: 99%
“…One such peptide is MOTS-c, which is encoded within the mitochondrial 12S rRNA gene and has been shown to protect against age-and diet-induced insulin resistance [35]. Many long and small noncoding RNAs have also been shown to be encoded in mammalian mtDNA, but their mode of action is currently unknown [36][37][38][39]. Furthermore, human mtDNA-coding sequences contain binding sites for nuclear transcription factors (e.g.…”
Section: Introductionmentioning
confidence: 99%