Small Nucleolar RNAs and Pre-rRNA Processing in Plants

Brown, John W.; Shaw, Peter J.

doi:10.2307/3870654

Cited by 9 publications

(14 citation statements)

References 37 publications

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“…AtY14 labels the nucleolus much more strongly than the nucleoplasm and, in particular, the peripheral nucleolar region. In addition it is located in foci in the nucleolar cavity (Beven et al, 1995;Brown and Shaw, 1998; Figure 3A). AtY14 is also concentrated in numerous small nucleoplasmic bodies compared with the faint, diffuse labeling of the nucleoplasm.…”

Section: Identification Of Exon Junction Complex Proteins In the Nuclmentioning

confidence: 95%

“…The localization of a variety of proteins, rRNA and snoRNA species to subdomains within plant nucleoli correlated well with early and late events in rRNA processing (Beven et al, 1996). From this, Brown and Shaw (1998) proposed a "vectorial" model of organization, in which successive biochemical steps in rRNA maturation and ribosome biogenesis occur in concentric layers enveloping the transcription sites. Finally, a distinctive feature of most plant nucleoli is a central region called the nucleolar cavity.…”

Section: Introductionmentioning

confidence: 99%

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Proteomic Analysis of theArabidopsisNucleolus Suggests Novel Nucleolar Functions

Pendle

Clark

Boon

et al. 2005

MBoC

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The eukaryotic nucleolus is involved in ribosome biogenesis and a wide range of other RNA metabolism and cellular functions. An important step in the functional analysis of the nucleolus is to determine the complement of proteins of this nuclear compartment. Here, we describe the first proteomic analysis of plant (Arabidopsis thaliana) nucleoli, in which we have identified 217 proteins. This allows a direct comparison of the proteomes of an important nuclear structure between two widely divergent species: human and Arabidopsis. The comparison identified many common proteins, plant-specific proteins, proteins of unknown function found in both proteomes, and proteins that were nucleolar in plants but nonnucleolar in human. Seventy-two proteins were expressed as GFP fusions and 87% showed nucleolar or nucleolar-associated localization. In a striking and unexpected finding, we have identified six components of the postsplicing exon-junction complex (EJC) involved in mRNA export and nonsense-mediated decay (NMD)/mRNA surveillance. This association was confirmed by GFP-fusion protein localization. These results raise the possibility that in plants, nucleoli may have additional functions in mRNA export or surveillance.

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Section: Identification Of Exon Junction Complex Proteins In the Nuclmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Proteomic Analysis of theArabidopsisNucleolus Suggests Novel Nucleolar Functions

Pendle

Clark

Boon

et al. 2005

MBoC

Self Cite

347

360

View full text Add to dashboard Cite

show abstract

“…The plant nucleolus is specific because it contains a unique feature in the center called the nucleolar cavity, also termed the 'nucleolar vacuole' [19]. The nucleolar cavity contains several immature small nucleolar (sno)RNAs, which are usually packed in sno-ribonucleoproteins (snoRNPs) and are key players in rRNA modification and pre-rRNA processing (Box 2) [20]. Thus, this region might be a place for the storage or preprocessing of snoRNAs [20].…”

Section: Specifics Of Plant Ribosome Biogenesismentioning

confidence: 99%

“…The nucleolar cavity contains several immature small nucleolar (sno)RNAs, which are usually packed in sno-ribonucleoproteins (snoRNPs) and are key players in rRNA modification and pre-rRNA processing (Box 2) [20]. Thus, this region might be a place for the storage or preprocessing of snoRNAs [20]. However, comprehensive studies of the role of the nucleolar cavity are lacking.…”

Section: Specifics Of Plant Ribosome Biogenesismentioning

confidence: 99%

Plant-Specific Features of Ribosome Biogenesis

Weis

Kovačević

Missbach

et al. 2015

Trends in Plant Science

130

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“…These modifications concern a wide number of rRNA nucleotides, nearly 200 in vertebrates and 100 in yeast but their effect on ribosome function remains unclear (3). All these early pre-rRNA processings occur in the dense fibrillar component of the nucleolus characterized by fibrillarin (4).…”

Section: Introductionmentioning

confidence: 99%