1997
DOI: 10.1101/gr.7.8.768
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Small Open Reading Frames: Beautiful Needles in the Haystack

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Cited by 214 publications
(205 citation statements)
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References 15 publications
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“…Because computational approaches typically exclude ORFs that are less than 100 aa (49,50), small proteins are likely missed, and their transcripts may be classified as ncRNAs (51,52). As shown by Western blot and mass spectrometry, at least some of the small ORFs we identified produce stable proteins.…”
Section: Discussionmentioning
confidence: 98%
“…Because computational approaches typically exclude ORFs that are less than 100 aa (49,50), small proteins are likely missed, and their transcripts may be classified as ncRNAs (51,52). As shown by Western blot and mass spectrometry, at least some of the small ORFs we identified produce stable proteins.…”
Section: Discussionmentioning
confidence: 98%
“…Proteins coded by small open reading frames (Ͻ100 amino acids) belong to a number of important categories, such as ATPase modulators, stress proteins, transcriptional regulators, and antioxidants (for review, see Ref. 25). To see whether the clone 17a gene is translated, a rabbit polyclonal antibody was generated against the synthetic peptide CSS-RGHEFNSQQPHGGSQPSVKRSD deduced from the clone F3 sequence (Fig.…”
Section: Figmentioning
confidence: 99%
“…This graph indicates a substantial drop off in the number of small proteins less than 101 amino acids, especially below 51 amino acids. It is even more striking when one considers that the number of theoretically possible ORFs increases exponentially as the size of the ORF allowed decreases (Basrai et al, 1997). The observed distribution may either reflect a biological basis (i.e.…”
mentioning
confidence: 98%