Small organic molecules accelerate the expansion of regulatory T cells

Afridi, Saifullah; Adnan, Musarrat; Hameed, Muhammad Waqar; Khalil, Abdul Wajid; Iqbal, Zafar; Hoessli, Daniel C.; Shahid, Muhammad; Khan, Shafi Ullah; Iqbal, Jamshed; Zhang, Xiaoming; Wu, Zhiyuan

doi:10.1016/j.bioorg.2021.104908

Cited by 4 publications

(5 citation statements)

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“…164,166 To date, only rapamycin has been reported as a selective Treg cell proliferator via an mTOR pathway activation and is used widely as a potent immune-suppressor in immunotherapy and autoimmune diseases. 166 CAs may provide a reservoir of structural diversity for the screening of Treg proliferators with oleracein E (64a) providing an interesting case in point. 166 64a strongly accelerated in vitro proliferation in all tested subsets of Treg cells, including naturally occurring thymus-derived, peripherally induced, or adaptive Treg.…”

Section: Marine Invertebratesmentioning

confidence: 99%

“…166 CAs may provide a reservoir of structural diversity for the screening of Treg proliferators with oleracein E (64a) providing an interesting case in point. 166 64a strongly accelerated in vitro proliferation in all tested subsets of Treg cells, including naturally occurring thymus-derived, peripherally induced, or adaptive Treg. These results indicated that the Treg proliferatory effects of 64a are independent of the Treg maturation site.…”

Section: Marine Invertebratesmentioning

confidence: 99%

“…In silico molecular docking has suggested that 64a may act on TCR, thereby different to rapamycin which acts on mTOR. 166 Janus kinases (JAKs) mediate intracellular signal transduction downstream of cytokines receptors via activation of transcription factor STAT signaling pathways. JAKs inhibitors suppress the effects of cytokines and have become a promising target for the treatment of autoimmune diseases.…”

Section: Marine Invertebratesmentioning

confidence: 99%

“…More importantly, this proliferation correlated with improved expression of CD4 + CD25 + FOXP3 + , the biomarkers for “Tregness” which confer suppressive activity. In silico molecular docking has suggested that 64a may act on TCR, thereby different to rapamycin which acts on mTOR …”

Section: Part V: Biological Activities Of Catecholamine Derivativesmentioning

confidence: 99%

“…Although occupying a low population (1–2%) in total lymphocytes, Treg cells occupy important roles for the prevention of autoimmune diseases by suppressing autoreactive lymphocytes. , To date, only rapamycin has been reported as a selective Treg cell proliferator via an mTOR pathway activation and is used widely as a potent immune-suppressor in immunotherapy and autoimmune diseases . CAs may provide a reservoir of structural diversity for the screening of Treg proliferators with oleracein E ( 64a ) providing an interesting case in point …”

Section: Part V: Biological Activities Of Catecholamine Derivativesmentioning

confidence: 99%

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Catecholamine Derivatives: Natural Occurrence, Structural Diversity, and Biological Activity

Tang,

Zhao,

Tao

et al. 2023

J. Nat. Prod.

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Catecholamines (CAs) are aromatic amines containing a 3,4-dihydroxyphenyl nucleus and an amine side chain. Representative CAs included the endogenous neurotransmitters epinephrine, norepinephrine, and dopamine. CAs and their derivatives are good resources for the development of sympathomimetic or central nervous system drugs, while they also provide ligands important for G-protein coupled receptor (GPCR) research. CAs are of broad interest in the fields of chemical, biological, medical, and material sciences due to their high adhesive capacities, chemical reactivities, metal-chelating abilities, redox activities, excellent biocompatibilities, and ease of degradability. Herein, we summarize CAs derivatives isolated and identified from microorganisms, plants, insects, and marine invertebrates in recent decades, alongside their wide range of reported biological activities. The aim of this review is to provide an overview of the structural and biological diversities of CAs, the regularity of their natural occurrences, and insights toward future research and development pertinent to this important class of naturally occurring compounds.

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