Small Post-Translationally Modified Peptide Signals in Arabidopsis

Matsubayashi, Yoshikatsu

doi:10.1199/tab.0150

Cited by 63 publications

(58 citation statements)

References 87 publications

(121 reference statements)

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“…The increased understanding of peptide signalling over the last two decades has established that secreted peptides principally have roles in local cell-to-cell communication within specific tissues in plants 32 . In this study, we provide the first indication that a secreted peptide ligand and a receptor kinase mediate longdistance organ-to-organ signalling that leads to a whole-plant systemic response.…”

Section: Discussionmentioning

confidence: 99%

Root-derived CLE glycopeptides control nodulation by direct binding to HAR1 receptor kinase

et al. 2013

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Leguminous plants establish a symbiosis with rhizobia to enable nitrogen fixation in root nodules under the control of the presumed root-to-shoot-to-root negative feedback called autoregulation of nodulation. In Lotus japonicus, autoregulation is mediated by CLE-RS genes that are specifically expressed in the root, and the receptor kinase HAR1 that functions in the shoot. However, the mature functional structures of CLE-RS gene products and the molecular nature of CLE-RS/HAR1 signalling governed by these spatially distant components remain elusive. Here we show that CLE-RS2 is a post-translationally arabinosylated glycopeptide derived from the CLE domain. Chemically synthesized CLE-RS glycopeptides cause significant suppression of nodulation and directly bind to HAR1 in an arabinose-chain and sequencedependent manner. In addition, CLE-RS2 glycopeptide specifically produced in the root is found in xylem sap collected from the shoot. We propose that CLE-RS glycopeptides are the long sought mobile signals responsible for the initial step of autoregulation of nodulation.

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Section: Discussionmentioning

confidence: 99%

Root-derived CLE glycopeptides control nodulation by direct binding to HAR1 receptor kinase

et al. 2013

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“…It will be interesting to elucidate the precise differential downstream signaling events via the same FLS2 receptor in response to different peptide ligands. A general future challenge in the emerging plant peptide-receptor signaling field is to elucidate the precise differential downstream signaling events via the same or different receptors in response to the potentially large spectrum of peptide ligands in various posttranslational modification forms (Jun et al 2008;Butenko et al 2009;Ohyama et al 2008;Matsubayashi 2011;Meng et al 2012).…”

Section: Discussionmentioning

confidence: 99%

“…We observed that the endogenously modified 12-amino-acid (aa) CLV3p triggered similar responses to flg22 (the conserved 22-aa peptide of bacterial flagellin) in mesophyll protoplasts (Asai et al 2002;Shan et al 2008;Lee et al 2011). This finding was unexpected because CLV3p is normally expressed, secreted, and processed by stem cells to control SAM maintenance via CLV1, CLV2, and other receptors (Kondo et al 2006;Jun et al 2008;Gish and Clark 2011;Matsubayashi 2011;Aichinger et al 2012 (Asai et al 2002;He et al 2006;Shan et al 2008;Boller and Felix 2009;Boudsocq et al 2010). Highly purified CLV3p synthesized by different sources displayed the same activities, ruling out the possibility of contamination.…”

Section: Clv3p-mediated Sam Immunitymentioning

confidence: 96%

“…Because CLV3p is specifically expressed and secreted from stem cells of the SAM (Kondo et al 2006;Jun et al 2008;Gish and Clark 2011;Matsubayashi 2011;Aichinger et al 2012), it is critical to examine CLV3p-FLS2 signaling in the SAM to evaluate its physiological relevance. Using quantitative reverse transcription -polymerase chain reaction (qRT-PCR) analysis with isolated SAM tissues, CLV3p clearly triggered two parallel signaling pathways in the SAM.…”

Section: Clv3p-mediated Sam Immunitymentioning

confidence: 99%

“…Molecular genetic and biochemical advances during past decades have revealed that peptides secreted and processed from and around stem cells have pivotal roles in controlling cell identity and developmental processes through multiple receptor kinase complexes in the SAM ( Fig. 1) (Kondo et al 2006;DeYoung and Clark 2008;Jun et al 2008;De Smet et al 2009;Guo et al 2010;Kinoshita et al 2010;Gish and Clark 2011;Matsubayashi 2011;Aichinger et al 2012;Perales and Reddy 2012;Song et al 2012). However, little is known about the dynamic biochemical, molecular, and cellular events and regulatory components constituting the primary signaling processes after peptide ligand perception by receptor kinases in the SAM (Betsuyaku et al 2011;Perales and Reddy 2012).…”

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confidence: 99%

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Stem Cell Signaling in Immunity and Development

Lee

Chah

Plotnikov

et al. 2012

Cold Spring Harbor Symposia on Quantitative Biology

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Stem cells in the shoot apical meristem (SAM) of plants are the self-renewable reservoir for leaf, stem, and flower organogenesis. Stem-cell fate and population size are subject to regulation by complex intrinsic signals and environmental cues to ensure balanced plant development, survival, and longevity. Peptides secreted from the shoot stem cells have pivotal roles in controlling cell identity, proliferation, and differentiation through multiple receptor kinase complexes. The best-characterized in vivo and in vitro peptide ligands are the 12-amino acid (aa) and the arabinosylated 13-aa CLAVATA3 peptides (CLV3p) that are perceived by multiple receptors with partially overlapping and distinct expression patterns and functions in the SAM. The primary molecular and cellular signaling mechanisms after the occurrence of ligand-receptor interaction remain elusive. Integrated analyses provide novel evidence for differential peptide-receptor signaling in the dynamic regulation of stem-cell homeostasis and fitness. Surprisingly, the 12-aa CLV3p can trigger immune signaling and limit pathogen invasion via the flagellin receptor kinase FLS2, suggesting a previously unrecognized molecular mechanism underlying enhanced immunity in the SAM area. Because pattern recognition receptor signaling in immune responses also profoundly intercepts plant development, peptide-receptor kinase signaling in immunity and development may share a common evolutionary origin.

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Comprehensive study and multipurpose role of the CLV3/ESR‐related (CLE) genes family in plant growth and development

Khan

Ahmar

et al. 2020

Journal Cellular Physiology

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The CLAVATA3/endosperm surrounding region‐related (CLE) is one of the most important signaling peptides families in plants. These peptides signaling are common in the cell to cell communication and control various physiological and developmental processes, that is cell differentiation and proliferation, self‐incompatibility, and the defense response. The CLE signaling systems are conserved across the plant kingdom but have a diverse mode of action in various developmental processes in different species. In this review, we concise various methods of peptides identification, structure, and molecular identity of the CLE family, the developmental role of CLE genes/peptides in plants, environmental stimuli, and CLE family and some other novel progress in CLE genes/peptides in various crops, and so forth. According to previous literature, about 1,628 CLE genes were identified in land plants, which deeply explained the tale of plant development. Nevertheless, some important queries need to be addressed to get clear insights into the CLE gene family in other organisms and their role in various physiological and developmental processes. Furthermore, we summarized the power of the CLE family around the environment as well as bifunctional activity and the crystal structure recognition mechanism of CLE peptides by their receptors and CLE clusters functions. We strongly believed that the discovery of the CLE family in other organisms would provide a significant breakthrough for future revolutionary and functional studies.

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Small Post-Translationally Modified Peptide Signals in Arabidopsis

Cited by 63 publications

References 87 publications

Root-derived CLE glycopeptides control nodulation by direct binding to HAR1 receptor kinase

Root-derived CLE glycopeptides control nodulation by direct binding to HAR1 receptor kinase

Stem Cell Signaling in Immunity and Development

Comprehensive study and multipurpose role of the CLV3/ESR‐related (CLE) genes family in plant growth and development

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