Small Preterm Infants (≤1500 g) Have Only a Sustained Decrease in Ventilation in Response to Hypoxia

Alvaro, Ruben; Alvarez, Jorge; Kwiatkowski, Kim; Cates, Don; Rigatto, Henrique

doi:10.1203/00006450-199210000-00007

Cited by 42 publications

(23 citation statements)

References 10 publications

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“…Preterm infants studied during quiet sleep behaved similarly. 24,25 Ventilatory responses to CO 2 tend to be relatively reproducible during QS. 26 Test-to-test variability of the VRMH appears to be greater, since in this study less than half the duplicate responses we elicited agreed.…”

Section: Discussionmentioning

confidence: 97%

Ventilatory response of the newborn infant to mild hypoxia

1997

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Section: Discussionmentioning

confidence: 97%

Ventilatory response of the newborn infant to mild hypoxia

1997

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“…20 These are the infants most likely to have apnea of prematurity. The preterm infants in our study may indeed have had only profound ventilatory depression with hypoxia in early postnatal life.…”

Section: Discussionmentioning

confidence: 99%

Relationship of the ventilatory response to hypoxia with neonatal apnea in preterm infants

Nock

DiFiore

Arko

et al. 2004

The Journal of Pediatrics

107

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“…In the group of preterm infants with birth weight <1500 g, there is no initial period of hyperventilation. 14 The decrease in ventilation is more pronounced in rapid eye movement sleep and is primarily because of a decrease in breathing frequency. The characteristic biphasic ventilatory response to hypoxia persists for 4 to 6 weeks in preterm infants.…”

Section: Peripheral Chemoreceptors and Impaired Hypoxic Ventilatory Rmentioning

confidence: 99%

Apnea of prematurity: pathogenesis and management strategies

Mathew

2010

J Perinatol

110

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Apnea of prematurity (AOP) is a significant clinical problem manifested by an unstable respiratory rhythm reflecting the immaturity of respiratory control systems. This review will address the pathogenesis of and treatment strategies for AOP. Although the neuronal mechanisms leading to apnea are still not well understood, recent decades have provided better insight into the generation of the respiratory rhythm and its modulation in the neonate. Ventilatory responses to hypoxia and hypercarbia are impaired and inhibitory reflexes are exaggerated in the neonate. These unique vulnerabilities predispose the neonate to the development of apnea. Treatment strategies attempt to stabilize the respiratory rhythm. Caffeine remains the primary pharmacological treatment modality and is presumed to work through blockade of adenosine receptors A 1 and A 2 . Recent evidences suggest that A 2A receptors may have a greater role than previously thought. AOP typically resolves with maturation suggesting increased myelination of the brainstem.

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Small Preterm Infants (≤1500 g) Have Only a Sustained Decrease in Ventilation in Response to Hypoxia

Cited by 42 publications

References 10 publications

Ventilatory response of the newborn infant to mild hypoxia

Ventilatory response of the newborn infant to mild hypoxia

Relationship of the ventilatory response to hypoxia with neonatal apnea in preterm infants

Apnea of prematurity: pathogenesis and management strategies

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