This chapter will cover the fundamentals of nuclear thermal propulsion systems, covering basic principles of operation and why nuclear is a superior option to chemical rockets for interplanetary travel. It will begin with a historical overview from early efforts in the early 1950s up to current interests, with respect to fuel types, core materials, and ongoing testing efforts. An overview will be provided of reactor types and design elements for reactor concepts or testing systems for nuclear thermal propulsion, followed by a discussion of nuclear thermal design concepts. A section on system design and modeling will be presented to discuss modeling and simulation of driving phenomena: neutronics, materials performance, heat transfer, and structural mechanics, solved in a tightly coupled multiphysics system. Finally, it will show the results of a coupled physics model for a conceptual design with simulation of rapid startup transients needed to maximize hydrogen efficiency.