2015
DOI: 10.1007/978-3-319-18881-2_3
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Small RNAs: Their Possible Roles in Reproductive Failure

Abstract: Posttranscriptional gene regulation is a regulatory mechanism which occurs "above the genome" and confers different phenotypes and functions within a cell. Transcript and protein abundance above the level of transcription can be regulated via noncoding ribonucleic acid (ncRNA) molecules, which potentially play substantial roles in the regulation of reproductive function. MicroRNA (miRNA), endogenous small interfering RNA (endo-siRNA), and PIWI-interacting RNA (piRNA) are three primary classes of small ncRNA. S… Show more

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Cited by 10 publications
(2 citation statements)
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“…The consequence of such deregulations is the emergence and development of various diseases. Elucidation of the role of specific non-coding RNAs in the context of disease leads to the potential use of miRNAs as biomarkers [34,46].…”
Section: Rna In Situ Hybridization At the Cellular Levelmentioning
confidence: 99%
“…The consequence of such deregulations is the emergence and development of various diseases. Elucidation of the role of specific non-coding RNAs in the context of disease leads to the potential use of miRNAs as biomarkers [34,46].…”
Section: Rna In Situ Hybridization At the Cellular Levelmentioning
confidence: 99%
“…Although the role of miRNAs in folliculogenesis is clear, the consequence of environmental toxicant exposure on miRNA expression and ovarian dysfunction is unknown. Moreover, toxicant‐induced infertility is thought to be regulated through changes in miRNA expression (Hale, Keating, Yang, & Ross, ) but miRNA dysregulation in the ovaries has yet to be determined. The mechanisms by which environmental chemicals interact with and modify miRNA expression are not well understood.…”
Section: Introductionmentioning
confidence: 99%