Small round tumour cells (CD38, CD 79a positive) in the adrenal gland

Nigam, Lovelesh K.; Vanikar, Aruna V; Kanodia, Kamal V; Patel, Rashmi D; Suthar, Kamlesh S

doi:10.1016/j.eucr.2017.09.009

Cited by 1 publication

(2 citation statements)

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“…Patients with low CD24 hi CD38 hi B‐cell frequency show high total cholesterol and low‐density lipoprotein cholesterol levels in hypertensive patients. It has also been reported that a reduction of regulatory B cells in CD24 hi CD38 hi in the peripheral blood is related to insulin resistance in patients with hypertension and is an independent risk factor for postprandial insulinemia (Nigam et al, 2018). These studies provide novel insight into the development of this pair of CD24 hi CD38 hi B‐cell‐related immune mechanisms (Figure 3).…”

Section: Effect Of Cd38 Expression On B‐cell Function and Its Potenti...mentioning

confidence: 99%

“…CD38 deficiency accelerates autoimmune processes such as autoimmune diabetes, lymphocyte proliferation, and rheumatoid arthritis (Domínguez‐Pantoja et al, 2018; Zhao et al, 2019). B cells are involved in periodontal immunomodulation, in which memory B cells (CD27 + CD38 − ) produce more RANKL supporting osteoclast differentiation, increasing osteoclasts and causing damage to periodontitis alveolar bone (Nigam et al, 2018). Researchers also found a new memory B‐cell population (CD19 + CD38 − CD24 − ), which was initially found to be more common in the elderly.…”

Section: Effect Of Cd38 Expression On B‐cell Function and Its Potenti...mentioning

confidence: 99%

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Effect of CD38 on B‐cell function and its role in the diagnosis and treatment of B‐cell‐related diseases

Zeng

Zhang

Jin

et al. 2022

Journal Cellular Physiology

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CD38 is a multifunctional receptor and enzyme present on the surface of B lymphocytes, which can induce B lymphocytes proliferation and apoptosis by crosslinking related cytokines to affect the function of B cells, thus affecting immune regulation in humans and promoting tumorigenesis. The level of CD38 expression in B cells has become an important factor in the clinical diagnosis, treatment, and prognosis of malignant tumors and other related diseases. Therefore, studying the relationship between CD38 expression on the surface of B cells and the occurrence of the disease is of great significance for elucidating its association with disease pathogenesis and the clinical targeted therapy. In this paper, we review the effects of CD38 on B‐cell activation, proliferation, and differentiation, and elaborate the functional role and mechanism of CD38 expression on B cells. We also summarize the relationship between the level of CD38 expression on the surface of B cells and the diagnosis, treatment, and prognosis of various diseases, as well as the potential use of targeted CD38 treatment for related diseases. This will provide an important theoretical basis for the scientific research and clinical diagnosis and treatment of B‐cell‐related diseases.

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Section: Effect Of Cd38 Expression On B‐cell Function and Its Potenti...mentioning

confidence: 99%

Section: Effect Of Cd38 Expression On B‐cell Function and Its Potenti...mentioning

confidence: 99%

Effect of CD38 on B‐cell function and its role in the diagnosis and treatment of B‐cell‐related diseases

Zeng

Zhang

Jin

et al. 2022

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

Small round tumour cells (CD38, CD 79a positive) in the adrenal gland

Cited by 1 publication

References 6 publications

Effect of CD38 on B‐cell function and its role in the diagnosis and treatment of B‐cell‐related diseases

Effect of CD38 on B‐cell function and its role in the diagnosis and treatment of B‐cell‐related diseases

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