Small scale, modular and continuous: A new approach in plant design

Seifert, Tim; Sievers, Stefan; Bramsiepe, Christian; Schembecker, Gerhard

doi:10.1016/j.cep.2011.10.007

Cited by 97 publications

(65 citation statements)

References 12 publications

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“…Reference size and price are usually provided by the supplier. The degression coefficients for the main apparatuses can vary significantly (Seifert et al 2012). Table 7.5 shows data, as typically found in the literature, compiled from Silla (2003), including the capacity of the reference device (always check the units given!…”

Section: Inside Battery Limits (Isbl) Costsmentioning

confidence: 99%

Processing of Biobased Resources

et al. 2017

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Section: Inside Battery Limits (Isbl) Costsmentioning

confidence: 99%

Processing of Biobased Resources

et al. 2017

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“…While evidence exists for continuous processing delivering financial benefits (mainly for single-purpose plants), these studies have largely been focused at the production and plant level [13], [14], [15], [16] with the overall business case in each case lacking an end-to-end supply network assessment. These case studies are discussed briefly later in this section.…”

Section: Methodology Development -Pharma Contextmentioning

confidence: 99%

Evaluating the potential for the continuous processing of pharmaceutical products—a supply network perspective

Srai

Harrington

Alinaghian

et al. 2015

Chemical Engineering and Processing: Process Intensification

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ABSTRACT:This paper presents an approach to evaluating the potential supply chain benefits of adopting continuous processing technologies for a diverse set of pharmaceutical products. The approach integrates upstream 'continuous' processing considerations for the production of active ingredients and final product formulation, with the downstream implications for packing and distribution. Currently, these upstream and downstream operations largely operate as decoupled operations with independent coordination and governance mechanisms, and the approach presented in this paper identifies opportunities for more case-specific integrated end-to-end supply chains enabled by continuous flow technologies. Three specific product (and corresponding processing technology) case studies are used to demonstrate the utility of the approach in assessing the supply network and system integration opportunities that emerge from the continuous processing of pharmaceutical products.

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“…While the manufacturing of those products is conventionally carried out in batch mode, continuous processing offers multiple advantages to improve product quality [2], cost efficiency [3], safety [4,5], and to reduce timeto-market [6]. In renowned research projects with the collaboration of both industry and academia innovative continuous production concepts have been successfully demonstrated [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Design of a Continuous Tubular Cooling Crystallizer for Process Development on Lab‐Scale

et al. 2016

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Continuous manufacturing of fine chemical, life science, and pharmaceutical products is under recent investigation in R&D. As cooling crystallization is an important unit operation for purification of products, continuously operated, scalable devices are required for process development on lab-scale. A tubular crystallizer was developed, based on the coiled flow inverter design. Experimental characterization proved a narrow residence time distribution of the liquid phase close to ideal plug flow. Counter-current air cooling allows for adjusting linear and curved temperature profiles. Unseeded operation with the L-alanine (water) system demonstrated that nucleation has to be actively controlled to successfully apply intensified continuous cooling crystallization processes.

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Small scale, modular and continuous: A new approach in plant design

Cited by 97 publications

References 12 publications

Processing of Biobased Resources

Processing of Biobased Resources

Evaluating the potential for the continuous processing of pharmaceutical products—a supply network perspective

Design of a Continuous Tubular Cooling Crystallizer for Process Development on Lab‐Scale

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