Small-sized versus standard magnetic capsule endoscopy in adults: a two-center, double-blinded randomized controlled trial

Abstract

Background Certain patients experience difficulty swallowing a video capsule endoscopy (VCE) device owing to its relatively large size. The newly developed small-sized magnetically controlled capsule endoscopy (MCE) device is the smallest VCE device ever reported. We aimed to evaluate the performance of the small-sized MCE device in terms of ingestion and examination efficacy. Methods Patients in two centers were prospectively enrolled and randomized to the small-sized or standard MCE groups. Differences in capsule ingestion difficulties, visualization of the gastrointestinal tract, and capsule transit times were compared. Results 96 patients were enrolled (48 in each group). In the small-sized MCE group, the mean (SD) difficulty score and time to swallow the capsule, and success rate for swallowing the capsule at the first attempt were 0.6 (1.0), 3.4 (1.3) seconds, and 89.6 %, which was significant better compared with the standard MCE group with 3.1 (1.7), 12.0 (14.3) seconds and 60.4 %, respectively (all P < 0.001). Visualization of the esophagus, stomach, and small bowel were comparable between the two groups. The small-sized MCE group had a significantly shorter gastric transit time (49.4 minutes vs. 66.2 minutes; P = 0.04) and longer small-bowel transit time (5.8 hours vs. 5.0 hours; P = 0.045). Conclusions The small-sized MCE device is feasible and safe for gastrointestinal examination, alleviating difficulties in capsule ingestion, improving gastric emptying under magnetic control, and prolonging the small-bowel transit time.

Diagnostic accuracy of magnetically guided capsule endoscopy with a detachable string for detecting oesophagogastric varices in adults with cirrhosis: prospective multicentre study

“…A smaller capsule could overcome this problem. 40 In addition, ds-MCE takes a longer time to perform than OGD and the cost of the disposable ds-MCE is higher than OGD, whereas ds-MCE does not require preoperative anaesthesia and postoperative recovery and enables a more thorough evaluation of the upper gastrointestinal tract and small bowel. Thus, a cost efficacy analysis is required in future studies.…”

Inadequate gastric preparation and its associated factors for magnetically controlled capsule endoscopy

“…Multiple large, prospective clinical studies have shown that MCE has considerable diagnostic efficacy in examining gastric lesions compared to gastroscopy ( Rey et al, 2012 ; Zou et al, 2015 ; Liao et al, 2016 ; Geropoulos et al, 2021 ; Li et al, 2021 ). Due to its minimal invasiveness and lack of sedation requirements, MCE has gained widespread acceptance as a diagnostic modality ( Eliakim, 2017 ; Jiang et al, 2022 ).…”