Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid

Heinen, Rutger; Groeneveld, Onno N.; Barkhof, Frederik; Bresser, Jeroen de; Exalto, Lieza G.; Kuijf, Hugo J.; Prins, Niels D.; Scheltens, Philip; Flier, Wiesje M. van der; Biessels, Geert Jan

doi:10.1002/dad2.12060

Cited by 11 publications

(8 citation statements)

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“…In line with the results of previous studies, our results suggest that brain atrophy determines cognitive impairment in elderly subjects with CSVD [ 7 , 53 ]. The relationship between brain atrophy and cognitive impairment is complex and is mediated by several factors including age, WMH load, (strategic) lacunes, CMBs, vascular risk factors and β−Amyloid deposition due to concomitant Alzheimer's pathology [ 54 , 55 ]. A longitudinal imaging study on CSVD patients investigating changes in diffusion and structural imaging described short-term changes in DTI parameters preceding (further) whole-brain atrophy and (progressive) cognitive deterioration [10] .…”

Section: Discussionmentioning

confidence: 99%

Cortical microstructural involvement in cerebral small vessel disease

Reiländer,

Engel,

Nöth

et al. 2024

Cerebral Circulation - Cognition and Behavior

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Section: Discussionmentioning

confidence: 99%

Cortical microstructural involvement in cerebral small vessel disease

Reiländer,

Engel,

Nöth

et al. 2024

Cerebral Circulation - Cognition and Behavior

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“…The most common forms are arteriosclerosis and cerebral amyloid angiopathy ( 35 ). However, there is currently limited research on the association between different types of SVD and brain atrophy ( 36 ). This may be the main future SVD research direction.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of international publication trends in brain atrophy research (2008–2023)

Wang,

Chen,

Xie

et al. 2024

Front. Neurol.

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BackgroundBrain atrophy is a type of neurological and psychiatric disorder characterized by a decrease in brain tissue volume and weight for various reasons and can have a serious impact on the quality of life of patients. Although there are many studies on brain atrophy, there is a lack of relevant bibliometric studies. Therefore, this study aims to provide a visual analysis of global trends in brain atrophy research over the past 16 years.MethodsCiteSpace and VOSviewer were used to visually analyze publication output, scientific collaborations, cocitations, publishing journals, and keywords to determine the current status and future trends of brain atrophy research. Materials published from 2008 to 2023 were collected from the Web of Science Core Collection (WoSCC) database. This study placed no restrictions on the types of literature and focused on English language publications.ResultsA total of 3,371 publications were included in the analysis. From 2008 to 2023, the number of publications increased annually. In terms of national and academic institutions, universities in the United States and University College London rank first in publication out. Barkhof Frederik and Zivadinov Robert are the most prolific researchers in this field. The publication with the highest cocitation strength is “Deep gray matter volume loss drives disability worsening in multiple sclerosis.” Keyword clustering analysis showed that “Alzheimer’s disease” and “multiple sclerosis” are current popular topics. The analysis of emergent words indicates that “cerebral small vessel disease,” “neurodegeneration,” and “cortex/gray matter volume” may become hot research topics in the coming years.ConclusionThis study analyses papers on brain atrophy from the past 16 years, providing a new perspective for research in this field. In the past 16 years, research on brain atrophy has received increasing attention. The quality of articles in this field is generally high. Extensive national cooperation already exists. The statistical results indicate that a stable core author group in the field of brain atrophy has almost formed.

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“… 14 , 15 , 16 Furthermore, several studies have shown that cerebrovascular disease MRI markers are associated with hippocampal and medial temporal brain volumes. 17 , 18 , 19 , 20 , 21 Despite this, very few autopsy‐based studies have examined the relationship between measures of intracranial atherosclerosis and MRI‐based measures of Alzheimer's dementia.…”

mentioning

confidence: 99%

Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure

Kapasi,

Capuano,

Lamar

et al. 2024

JAHA

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Background Lower hippocampal volume is associated with late‐life cognitive decline and is an important, but nonspecific marker for clinical Alzheimer's dementia. Cerebrovascular disease may also be associated with hippocampal volume. Here we study the role of intracranial large vessel disease (atherosclerosis) in association with hippocampal volume and the potential role of age, average late‐life blood pressure across all visits, and other factors (sex, apolipoprotein ε4 [ APOE ε4], and diabetes). Methods and Results Data came from 765 community‐based older people (91 years old on average at death; 72% women), from 2 ongoing clinical‐pathologic cohort studies. Participants completed baseline assessment, annual standardized blood pressure measurements, vascular risk assessment for diabetes, and blood draws to determine APOE genotype, and at death, brains were removed and underwent ex vivo magnetic resonance imaging and neuropathologic evaluation for atherosclerosis pathology and other cerebrovascular and neurodegenerative pathologies. Linear regression models examined the association of atherosclerosis and hippocampal to hemisphere volume ratio and whether age at death, blood pressure, and other factors modified associations. In linear regression models adjusted for demographics and neurodegenerative and other cerebrovascular pathologies, atherosclerosis severity was associated with a lower hippocampal to hemisphere volume ratio. In separate models, we found the effect of atherosclerosis on the ratio of hippocampal to hemisphere volume was attenuated among advanced age at death or having higher systolic blood pressure (interaction terms P ≤0.03). We did not find confounding or interactions with sex, diabetes, or APOE ε4. Conclusions Atherosclerosis severity is associated with lower hippocampal volume, independent of neurodegenerative and other cerebrovascular pathologies. Higher systolic blood pressures and advanced age attenuate associations.

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Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid

Cited by 11 publications

References 50 publications

Cortical microstructural involvement in cerebral small vessel disease

Cortical microstructural involvement in cerebral small vessel disease

A bibliometric analysis of international publication trends in brain atrophy research (2008–2023)

Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure

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