Small volume laboratory on a chip measurements incorporating the quartz crystal microbalance to measure the viscosity-density product of room temperature ionic liquids

Doy, Nicola; McHale, Glen; Newton, Michael I.; Hardacre, Christopher; Ge, Rile; MacInnes, J.M.; Kuvshinov, Dmitriy; Allen, Ray

doi:10.1063/1.3353379

Cited by 21 publications

(14 citation statements)

References 19 publications

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“…), with an increasing number of papers covering interactions with carbohydrates. Applications to small molecule detection in particular were particularly abundant and diverse, with references ranging from molecular imprinted polymer interactions with small molecules (Pietrzyk et al ., ), ions binding to crown ethers (Schuwer and Klok, ), catechins binding to cardiac troponin C (Tadano et al ., ), cancer drug action on human cell lines (Kang et al ., ), through to measurements of viscosity and density of ionic liquids (Doy et al ., ). These references highlight the versatility of QCM for the detection of analytes with a wide variety of molecular sizes.…”

Section: Publication Trendsmentioning

confidence: 97%

“…The sensors were chemoselective due to specific chemical reactivities, were stable and could easily be regenerated. Furthermore, the density‐viscosity product of ionic liquids could be determined using QCM (Doy et al ., ). Aliphatic aldehyde and ketone vapours were also detected by adsorption on a stable polystyrene sensor (Mirmohseni and Olad, ).…”

Section: Small Molecule Interactionsmentioning

confidence: 97%

See 1 more Smart Citation

A Survey of the 2010 Quartz Crystal Microbalance Literature

Speight

Cooper

2012

J of Molecular Recognition

135

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In 2010 there has again been an increase in the number of papers published involving piezoelectric acoustic sensors, or quartz crystal microbalances (QCM), when compared to the last period reviewed 2006-2009. The average number of QCM publications per annum was 124 in the period 2001-2005, 223 in the period 2006-9, and 273 in 2010. There are trends towards increasing use of QCM in the study of protein adsorption to surfaces (93% increase), homeostasis (67% increase), protein-protein interactions (40% increase), and carbohydrates (43% increase). New commercial systems have been released that are driving the uptake of the technology for characterisation of binding specificities, affinities, kinetics and conformational changes associated with a molecular recognition event. This article highlights theoretical and practical aspects of the principals that underpin acoustic analysis, then reviews exemplary papers in key application areas involving small molecular weight ligands, carbohydrates, proteins, nucleic acids, viruses, bacteria, cells, and membrane interfaces.

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Section: Publication Trendsmentioning

confidence: 97%

Section: Small Molecule Interactionsmentioning

confidence: 97%

A Survey of the 2010 Quartz Crystal Microbalance Literature

Speight

Cooper

2012

J of Molecular Recognition

135

View full text Add to dashboard Cite

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“…In contrast to classical methods, the study of rheology through microfluidic techniques is a widely used method to analyze the viscosity of complex fluids. Several microfluidic platforms have been developed to reach high confinement levels [ 9 , 10 , 11 ] (and thus, high precision), such as broader shear rate crystal microbalance (QCM) [ 12 ], laser-induced capillary wave [ 13 ], and the use of multiple microfluidic channels. This relatively new field has come up with some viscometers that measure viscosity as a function of shear rate and temperature, although most of them are not applied in biofluids.…”

Section: Introductionmentioning

confidence: 99%

Microrheometer for Biofluidic Analysis: Electronic Detection of the Fluid-Front Advancement

et al. 2021

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The motivation for this study was to develop a microdevice for the precise rheological characterization of biofluids, especially blood. The method presented was based on the principles of rheometry and fluid mechanics at the microscale. Traditional rheometers require a considerable amount of space, are expensive, and require a large volume of sample. A mathematical model was developed that, combined with a proper experimental model, allowed us to characterize the viscosity of Newtonian and non-Newtonian fluids at different shear rates. The technology presented here is the basis of a point-of-care device capable of describing the nonlinear rheology of biofluids by the fluid/air interface front velocity characterization through a microchannel. The proposed microrheometer uses a small amount of sample to deliver fast and accurate results, without needing a large laboratory space. Blood samples from healthy donors at distinct hematocrit percentages were the non-Newtonian fluid selected for the study. Water and plasma were employed as testing Newtonian fluids for validation of the system. The viscosity results obtained for the Newtonian and non-Newtonian fluids were consistent with pertinent studies cited in this paper. In addition, the results achieved using the proposed method allowed distinguishing between blood samples with different characteristics.

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“…However, the main limitation of such acoustic wave sensors is that they are not able to differentiate a liquid's viscosity and density [16,17]. The frequency response of the acoustic wave sensors is proportional to the square root of viscosity density product [10,18,19]. Although many devices have been claimed as viscosity sensors, they actually assume that density is constant and overlook its influence.…”

Section: Introductionmentioning

confidence: 99%

Viscosity and density decoupling method using a higher order Lamb wave sensor

Wang

Kropelnicki

et al. 2014

J. Micromech. Microeng.

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Viscosity and density are two important physical parameters of liquid. Such parameters are widely used for label-free chemical detection. Conventional technologies employ acoustic wave sensors to detect viscosity and density. In these sensors, the liquid under test directly contacts with the surface of the sensor. The produced acoustic wave in the sensor leaks to the adjacent liquid layer, causing a shift in the resonance frequency of the sensor. However, such sensors are not able to separately measure the viscosity and density because these two parameters jointly affect the shift of frequency. Although some indirect methods for decoupling these two parameters have been investigated, either dual-device or simultaneous measurement of frequency and attenuation is required. In this paper, a novel AlN based acoustic wave sensor is developed for decoupling viscosity and density. Multiple higher order modes of Lamb waves are generated in this sensor and employed to interact with the adjacent liquid under test. The frequency change of two unique modes (mode C and mode D) has been found in a linear relationship with viscosity and density, respectively. With this unique feature, viscosity and density of a liquid can be distinguished by a single device, which is promising for potential industrial applications, label-free chemical detection and clinical diagnosis.

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Small volume laboratory on a chip measurements incorporating the quartz crystal microbalance to measure the viscosity-density product of room temperature ionic liquids

Cited by 21 publications

References 19 publications

A Survey of the 2010 Quartz Crystal Microbalance Literature

A Survey of the 2010 Quartz Crystal Microbalance Literature

Microrheometer for Biofluidic Analysis: Electronic Detection of the Fluid-Front Advancement

Viscosity and density decoupling method using a higher order Lamb wave sensor

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