2021
DOI: 10.24321/2349.7181.202112
|View full text |Cite
|
Sign up to set email alerts
|

Small Volume of Rabies Immunoglobulin (RIG) is Effective for Local Wound Infiltration in Rabies Post-Exposure Prophylaxis whereas Intramuscular RIG is just a Wastage

Abstract: Rabies is a zoonosis that is 100% fatal once symptoms of the disease appear. However, it is almost 100% preventable if the prophylactic measures with proper wound wash, vaccines and immunoglobulins are taken soon after exposure to the animal bite. A general tendency has been noticed among clinicians all over the world to inject Rabies Immunoglobulins (RIG) intramuscularly, mostly in the gluteal muscle, despite the guidelines that suggest infiltrating it into the wounds. This has resulted in failures of Post Ex… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2022
2022
2022
2022

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(2 citation statements)
references
References 18 publications
0
2
0
Order By: Relevance
“…18 We have also used diluted eRIG in many cases having wounds on the head and neck without failure and have advocated that even a small volume of RIG covering the surface of the wound till depth is effective for rabies PEP. 19 A 4-yearold girl who was seriously bitten by a confirmed rabid dog in rural China survived with only wounds infiltration of hRIG diluted 15 times to a concentration of 33.33 IU/ml. 20 Therefore, there is no need of using concentrated RIG for wounds on highly innervated areas like the head and neck and expanding the categories to category IV, however, all wounds/ scratches should be carefully assessed, washed with soap and water, and RIG infiltration should be done to cover the surface of the wound(s) till depth along with rabies vaccination for effective rabies PEP.…”
Section: Discussionmentioning
confidence: 99%
“…18 We have also used diluted eRIG in many cases having wounds on the head and neck without failure and have advocated that even a small volume of RIG covering the surface of the wound till depth is effective for rabies PEP. 19 A 4-yearold girl who was seriously bitten by a confirmed rabid dog in rural China survived with only wounds infiltration of hRIG diluted 15 times to a concentration of 33.33 IU/ml. 20 Therefore, there is no need of using concentrated RIG for wounds on highly innervated areas like the head and neck and expanding the categories to category IV, however, all wounds/ scratches should be carefully assessed, washed with soap and water, and RIG infiltration should be done to cover the surface of the wound(s) till depth along with rabies vaccination for effective rabies PEP.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, we need more than 0.5 IU/ml titers of eRIG for only wound infiltration, which was supposed to be there even if eRIG was expired. 7 One human being was given due vaccine and eRIG that was not expired.…”
Section: Living Subjects (Animals/ Human)mentioning
confidence: 99%