2011
DOI: 10.1021/jp1111394
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Smart Approach To Evaluate Drug Diffusivity in Injectable Agar−Carbomer Hydrogels for Drug Delivery

Abstract: Hydrogels are commonly studied for tissue engineering applications and controlled drug delivery. In order to evaluate their reliability as scaffolds and delivery devices, literature describes many release studies performed involving different analytical techniques. However, these experiments can be expensive, time-consuming, and often not reproducible. In this study, two injectable agar-carbomer-based hydrogels were studied, both being loaded with sodium fluorescein, a harmless fluorophore with a steric hindra… Show more

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Cited by 86 publications
(90 citation statements)
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“…The gelling solution was then placed in steel cylinders (0.5 mL each and with the same dimensions of a standard well in a 48-plate) and left to stabilize at 37 °C until reaching complete gelation. The formation of ester bonds between hydroxyl groups of agarose and carboxyl ones of carbomer was described in previous works, where we discussed the chemical nature of agarose-carbomer based hydrogels 53,54 . Acronyms of hydrogels are harmonized with previous studies 52 .…”
Section: Hydrogel Synthesis and Drug Loadingmentioning
confidence: 90%
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“…The gelling solution was then placed in steel cylinders (0.5 mL each and with the same dimensions of a standard well in a 48-plate) and left to stabilize at 37 °C until reaching complete gelation. The formation of ester bonds between hydroxyl groups of agarose and carboxyl ones of carbomer was described in previous works, where we discussed the chemical nature of agarose-carbomer based hydrogels 53,54 . Acronyms of hydrogels are harmonized with previous studies 52 .…”
Section: Hydrogel Synthesis and Drug Loadingmentioning
confidence: 90%
“…As shown in previous works 54 , the classic Fick model applied to the drug release experiments provides reliable diffusion coefficient for low concentration of drugs, but cannot be used to study the concentration effect on mass transport. It is well known that, in the absence of drug concentration gradient (as in the present case), drug release rate is not expected to be influenced by its concentration 62 .…”
Section: Modeling Ip Diffusion Coefficients In Gelmentioning
confidence: 99%
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“…The latter derives from disaccharide agarobiose units sided by 3-linked β-D-galactopyranosyl and 4-linked 3,6-anhydro-α-L-galactopyranosyl units [17]. Thanks to its gelling properties, agar is applied in several different fields: in biology for the preparation of culture media [18], in chemistry as electrode binder for electrolyte cells [19], in pharmacy for drug delivery [20], in the food industry as thickening agent. Once the agar powder is mixed in water suspension and heated up to 80°C, it develops a random coil structure which is able to progressively rearrange and gel during the cooling stage, below 40°C.…”
Section: Introductionmentioning
confidence: 99%
“…Chondroitinase ABC (chABC), although capable of digesting these proteoglycans leading to the degradation of glial scar and favoring axonal regrowth, suffers from delivery drawbacks such as administration being invasive, infection-prone and clinically problematic. Rossi et al, 2012, developed an agarose-carbomer (AC1) hydrogel, which they previously used in SCI repair strategies [26][27][28], as a delivery system capable of an effective chABC administration based on following considerations: ability to include chABC within its pores and the possibility to be injected into the target tissue; and release kinetics and the maintenance of enzymatic activity can be positively assessed. Additionally, being a hydrogel, AC1 had its own advantages in terms of (I) the ability to retain water; (II) mimicking living tissues; (III) high biocompatibility; and (IV) the possibility to allow precisely controlled release rates.…”
Section: Sustained Delivery Of Chondroitinase Abc From Hydrogel Systemmentioning
confidence: 99%