Smart Bioceramics for Orthopedic Applications

Depboylu, Fatma Nur; Korkusuz, Petek; Yasa, Evren; Korkusuz, Feza

doi:10.1007/978-981-16-7439-6_8

Cited by 3 publications

(2 citation statements)

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“…[9][10][11][12] Among them, hydroxyapatite and tri-calcium phosphate have been widely focused on dental and orthopedic applications. 13 Rather than these two phases, the other translation of CP phases and characteristics of these materials at the nanoscale remains unrevealed yet. In this study, we synthesized calcium phosphate through the hydrothermal method at three different pH values ranging from slight acidic (M-CP), neutral (MH-CP), and alkaline (H-CP) then their characteristic were examined by structural, morphological, functional analysis and also unique pro-angiogenic properties.…”

Section: Introductionmentioning

confidence: 99%

“…The CP appears in various phases including Hydroxyapatite (Ca 10 [PO 4 ] 6 (OH) 2 ), Octacalcium phosphate (Ca 8 H 2 [PO 4 ] 6 .5H 2 O), Monetite (CaHPO 4 ), 8 Brushite (CaHPO 4 .2H 2 O), α and β Tricalcium phosphate (α and β‐Ca 3 [PO 4 ] 2 ), Tetracalcium phosphate (Ca 4 [PO 4 ] 2 O), and Calcium pyrophosphate dihydrate (Ca 2 P 2 O 7 .2H 2 O) and so forth 9–12 . Among them, hydroxyapatite and tri‐calcium phosphate have been widely focused on dental and orthopedic applications 13 . Rather than these two phases, the other translation of CP phases and characteristics of these materials at the nanoscale remains unrevealed yet.…”

Section: Introductionmentioning

confidence: 99%

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Influence of pH in the synthesis of calcium phosphate based nanostructures with enhanced bioactivity and pro‐angiogenic properties

2022

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In synthetic fabrication, the process parameters decide the growth nucleation, phase translation, and the evolution of morphological facets of nanostructured materials. This work demonstrates the formation of different crystallographic phases of calcium phosphate by the influence of pH from acidic to alkaline conditions and also investigated their bone regeneration, protein adsorption, and pro‐angiogenic properties. Present results illustrate that the alteration of pH is the crucial factor for the synthesis of calcium phosphate (CP) phases. The structural analysis reveals the monetite (CaHPO4) phase with a triclinic crystal system for pH 5, dual‐phase of monetite combined with hydroxyapatite at the neutral pH 7, and pure phase of hydroxyapatite (Ca10[PO4]6OH2) with hexagonal structure at pH 10. Microscopic analysis portrays the cubic and rod‐like morphologies by changing the pH values. FTIR and RAMAN spectroscopic analyses confirm the stretching, bending, and vibrational modes of dominant phosphate groups of different CP phases. Further, the biocompatibility of the prepared CP phases was examined by hemolysis assay, which showed less than 2% of lysis and enhanced cell viability. Moreover, the bioactivity study revealed rapid mineralization and a higher protein adsorption rate for the monetite CP phase (M‐CP). Subsequently, the chick embryo angiogenesis assay elucidated 33% higher neovascularization for M‐CP compared with the other two CP phases. The fabricated M‐CP nanostructure constitutes a promising candidate for biomedical applications.

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