“…However, as brain is protected by skull, a high strength bio-composite material with micro-porosities, this natural barrier needs to be penetrated for the insertion of micro-tools for minimally invasive neural intervention. Perforation of skull bone is conventionally achieved by material-removal techniques such as drilling/grinding [5,6]. Due to the high strength of skull bone (Young's modulus of 22-45 GPa [7]), a micro drill bit would easily fracture under a large thrust force, making it difficult to safely generate a micro-hole on skull by drilling.…”