Smart biosensors and intelligent devices for salivary biomarker detection

Zheng, Xufeng; Zhang, Fanrou; Wang, Kun; Zhang, Wei; Li, Yige; Sun, Yue; Sun, Xin; Li, Chunyan; Dong, Biao; Wang, Lin; Xu, Lin

doi:10.1016/j.trac.2021.116281

Cited by 78 publications

(38 citation statements)

References 153 publications

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“…Saliva is a complex biological substance consisting of numerous intracellular or extracellular components that have permeated from the blood [39][40][41][42]. Therefore, saliva is an excellent noninvasive alternative sample to blood analysis for monitoring the emotional, hormonal, nutritional, and metabolic status of the human body.…”

Section: Saliva-based Biosensorsmentioning

confidence: 99%

Biosensors and Chemical Sensors for Healthcare Monitoring: A Review

Arakawa

Dao

Mitsubayashi

2022

IEEJ Transactions Elec Engng

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Biosensors and chemical sensors for healthcare applications are garnering interest due to their potential to provide continuous and real-time physiological information, chemical information, and noninvasive measurements of biochemical markers in human biofluids, such as tears, saliva, sweat, interstitial fluid, and human volatiles. Recent developments have focused on electrochemical biosensors and monitoring of metabolites, proteins, chemicals, and bacteria. The measurement of biophysical quantities of the human body has been studied in healthcare and medicine. Many flexible, wearable, and detachable sensors have been developed and commercialized to monitor relevant parameters in sports, healthcare, and medicine. Here, we introduce many challenges regarding the integration of sensors and biosensors into the monitoring of biological and chemical information for the internet of things (IoT) in healthcare. IoT sensors are set to improve quality of life (QoL) and living standards.

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Section: Saliva-based Biosensorsmentioning

confidence: 99%

Biosensors and Chemical Sensors for Healthcare Monitoring: A Review

Arakawa

Dao

Mitsubayashi

2022

IEEJ Transactions Elec Engng

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“…CNT paste was produced of brumoform, and the electrode was designed with superior enactment over all other carbon electrodes [172]. Bioaffinity electrochemical biosensors are very robust complexes [173] in CNT-DNA electrochemical biosensors have been designed to acquire a simple, cheap, fast sensor [174]. Figure 11 shows the applications of biosensors from nanocomposite.…”

Section: 2mentioning

confidence: 99%

Sustainable Development of Carbon Nanocomposites: Synthesis and Classification for Environmental Remediation

Veeman¹,

Shree²,

Sureshkumar³

et al. 2021

Journal of Nanomaterials

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Composite materials with carbon nanotube and graphene attachments have been regarded as promising prospects. Carbon nanocomposites have gained considerable interest in different fields including biomedical applications due to its exceptional structural dimensions and outstanding mechanical, electrical, thermal, optical, and chemical characteristics. The significant advances made in carbon nanocomposite over past years along with the discovery of new nanocomposite processing technologies to improvise the functional impact of nanotube and graphene composites by providing proper methods of synthesis and improving the production of diverse composite based on carbon nanomaterials are discussed. Carbon nanocomposites are applied in various fields such as aviation, batteries, chemical industry, fuel cell, optics, power generation, space, solar hydrogen, sensors, and thermoelectric devices. The recent design, fabrication, characteristics, and applications of carbon nanocomposites such as active carbon, carbon black, graphene, nanodiamonds, and carbon nanotubes are explained in detail in this research. It is found that unlike traditional fiber composites, Van der Waals force interfacial compounds have an important effect on the mechanical performance of carbon nanomaterial-based composites.

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“…This allows the sensor to be prepared for the appropriate application. Electrochemical biosensors are also widely used outside the analysis of DNA–molecule interactions in the detection and quantification of chemicals such as drugs, metabolites, pollutants, biomarkers etc [ 69 , 74 , 75 , 76 , 77 , 78 ].…”

Section: Electrochemical Approach To Dna–drug Interaction Descriptionmentioning

confidence: 99%

What Can Electrochemical Methods Offer in Determining DNA–Drug Interactions?

2021

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The interactions of compounds with DNA have been studied since the recognition of the role of nucleic acid in organisms. The design of molecules which specifically interact with DNA sequences allows for the control of the gene expression. Determining the type and strength of such interaction is an indispensable element of pharmaceutical studies. Cognition of the therapeutic action mechanisms is particularly important for designing new drugs. Owing to their sensitivity, simplicity, and low costs, electrochemical methods are increasingly used for this type of research. Compared to other techniques, they require a small number of samples and are characterized by a high reliability. These methods can provide information about the type of interaction and the binding strength, as well as the damage caused by biologically active molecules targeting the cellular DNA. This review paper summarizes the various electrochemical approaches used for the study of the interactions between pharmaceuticals and DNA. The main focus is on the papers from the last decade, with particular attention on the voltammetric techniques. The most preferred experimental approaches, the electrode materials and the new methods of modification are presented. The data on the detection ranges, the binding modes and the binding constant values of pharmaceuticals are summarized. Both the importance of the presented research and the importance of future prospects are discussed.

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Smart biosensors and intelligent devices for salivary biomarker detection

Cited by 78 publications

References 153 publications

Biosensors and Chemical Sensors for Healthcare Monitoring: A Review

Biosensors and Chemical Sensors for Healthcare Monitoring: A Review

Sustainable Development of Carbon Nanocomposites: Synthesis and Classification for Environmental Remediation

What Can Electrochemical Methods Offer in Determining DNA–Drug Interactions?

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