Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots

Iannazzo, Daniela; Espro, Claudia; Celesti, Consuelo; Ferlazzo, Angelo; Neri, G.

doi:10.3390/cancers13133194

Cited by 52 publications

(27 citation statements)

References 145 publications

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“…Cancer patient survival rates are low due to some variables, including late-stage detection, the toxicity of anticancer treatment, and the poor response of many cancer types to therapy [ 31 , 32 ]. Targeted therapeutic approaches have been investigated in research and clinical practice to reduce the harmful side effects of conventional cancer therapies while maximizing the desired therapeutic benefits [ 33 ].…”

Section: Electrospun Nf Implantsmentioning

confidence: 99%

Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine

et al. 2022

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Electrospinning (ES) has become a straightforward and customizable drug delivery technique for fabricating drug-loaded nanofibers (NFs) using various biodegradable and non-biodegradable polymers. One of NF's pros is to provide a controlled drug release through managing the NF structure by changing the spinneret type and nature of the used polymer. Electrospun NFs are employed as implants in several applications including, cancer therapy, microbial infections, and regenerative medicine. These implants facilitate a unique local delivery of chemotherapy because of their high loading capability, wide surface area, and cost-effectiveness. Multi-drug combination, magnetic, thermal, and gene therapies are promising strategies for improving chemotherapeutic efficiency. In addition, implants are recognized as an effective antimicrobial drug delivery system overriding drawbacks of traditional antibiotic administration routes such as their bioavailability and dosage levels. Recently, a sophisticated strategy has emerged for wound healing by producing biomimetic nanofibrous materials with clinically relevant properties and desirable loading capability with regenerative agents. Electrospun NFs have proposed unique solutions, including pelvic organ prolapse treatment, viable alternatives to surgical operations, and dental tissue regeneration. Conventional ES setups include difficult-assembled mega-sized equipment producing bulky matrices with inadequate stability and storage. Lately, there has become an increasing need for portable ES devices using completely available off-shelf materials to yield highly-efficient NFs for dressing wounds and rapid hemostasis. This review covers recent updates on electrospun NFs in nanomedicine applications. ES of biopolymers and drugs is discussed regarding their current scope and future outlook.

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Section: Electrospun Nf Implantsmentioning

confidence: 99%

Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine

et al. 2022

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“…As is known, zero-dimensional graphene quantum dots GQDs, a member of the latest-generation graphene family, have also attracted great interest from researchers and industries in recent years [ 171 ]. In line with the developments in this field, it is thought that graphene oxide and reduced graphene oxide nanomaterials in biosensors will replace them, and it is predicted that the potential of clinical validity in cancer diagnosis will be great, based on the wide linear detection ranges and low detection limits of GQDs-based biosensors reported so far.…”

Section: Challenges and Future Outlookmentioning

confidence: 99%

Current Perspectives in Graphene Oxide-Based Electrochemical Biosensors for Cancer Diagnostics

Ozkan-Ariksoysal

2022

Biosensors

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Since the first commercial biosensor device for blood glucose measurement was introduced in the 1970s, many “biosensor types” have been developed, and this research area remains popular worldwide. In parallel with some global biosensor research reports published in the last decade, including a great deal of literature and industry statistics, it is predicted that biosensor design technologies, including handheld or wearable devices, will be preferred and highly valuable in many areas in the near future. Biosensors using nanoparticles still maintain their very important place in science and technology and are the subject of innovative research projects. Among the nanomaterials, carbon-based ones are considered to be one of the most valuable nanoparticles, especially in the field of electrochemical biosensors. In this context, graphene oxide, which has been used in recent years to increase the electrochemical analysis performance in biosensor designs, has been the subject of this review. In fact, graphene is already foreseen not only for biosensors but also as the nanomaterial of the future in many fields and is therefore drawing research attention. In this review, recent and prominent developments in biosensor technologies using graphene oxide (GO)-based nanomaterials in the field of cancer diagnosis are briefly summarized.

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“…A growing interest has been evident with a surge in research on novel QD families such as graphene QDs, 26 and QD-based biomedical detection has been flourishing over the past decade in cancer theranostics. [27][28][29] Despite the recent reports on the successful application of multiplexed fluorescent QD-based nanoprobes that simultaneously detect three biomarkers of lung cancer, 30 multiplexed fluorescence detection of more than two liver cancer biomarkers remains unexplored.…”

Section: Introductionmentioning

confidence: 99%

An Approach to the Simultaneous Detection of Multiple Biomarkers for the Early Diagnosis of Liver Cancer Using Quantum Dot Nanoprobes

Cheng

2022

Infectious Microbes and Diseases

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Biomarker-based early diagnosis of liver cancer is of high clinical value for reducing the mortality rate. However, it has been challenging to establish early detection methods with a single biomarker such as alpha-fetoprotein (AFP) because of limited diagnostic sensitivity and specificity. Therefore, developing multiplexed biomarker detection assays is crucially important for early diagnosis. Yet, simultaneous detection methods involving three or more biomarkers have been scarce. Here we suggest employing the serological biomarker panel of glypican-3 (GPC3), dickkopf-1 (DKK1), and AFP for liver cancer detection. We present a rapid simultaneous detection approach for the biomarker panel labeled with three fluorescent quantum dot nanoprobes (emission wavelengths at 565 nm, 605 nm, and 655 nm). As a proof-of-concept, simultaneous fluorescence detection of the biomarker panel was demonstrated using mixed reference samples containing human recombinant GPC3, DKK1, and AFP antigens. Our simultaneous detection approach conferred a linear range of 0.625-2.5 ng•mL À1 for the entire biomarker panel, which merits further clinical validation for the simultaneous and accurate determination of the biomarker panel in human serum samples.

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Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots

Cited by 52 publications

References 145 publications

Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine

Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine

Current Perspectives in Graphene Oxide-Based Electrochemical Biosensors for Cancer Diagnostics

An Approach to the Simultaneous Detection of Multiple Biomarkers for the Early Diagnosis of Liver Cancer Using Quantum Dot Nanoprobes

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