Smart Contact Lenses for Healthcare Monitoring and Therapy

Liu, Xiaohu; Ye, Ying; Ge, Yuancai; Qu, Jia; Liedberg, Bo; Zhang, Qingwen; Wang, Yi

doi:10.1021/acsnano.3c12072

Cited by 12 publications

(1 citation statement)

References 183 publications

(460 reference statements)

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“…Intraocular pressure (IOP), the pressure within the eye, must be consistently monitored to prevent significant ocular diseases such as glaucoma and ocular hypertension [103][104][105] . Smart contact lenses with DDSs have been reported for IOP response but faced some issues such as low sensitivity, biocompatibility, and stability for long-term IOP monitoring [106,107] .…”

Section: Vital Monitoring Devicesmentioning

confidence: 99%

Body-attachable multifunctional electronic skins for bio-signal monitoring and therapeutic applications

Kim,

et al. 2024

Soft Sci

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The lack of infrastructure and accessibility in medical treatments has been considered as a global chronic issue since the concept of treatment and prevention was presented. After the COVID-19 pandemic, the medical reaction capability for epidemic outbreak/spread has been spotlighted as a critical issue to the fore worldwide. To reduce the burden on the medical system from the simultaneous disease emergence, the personalized wearable electronic systems have arisen as the next-generation biomedical monitoring/treating equipment for infectious diseases at the initial stage. In particular, electronic skin (e-skin) with its potential for multifunctional extendibility has been enabled to be applied to next-generation long-term healthcare devices with real-time biosignal sensing. Here, we introduce the recent enhancements of various e-skin systems for healthcare applications in terms of material types and device structures, including sensor components, biological signal sensing mechanisms, applicable technological advancements, and medical utilization.

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Section: Vital Monitoring Devicesmentioning

confidence: 99%

Body-attachable multifunctional electronic skins for bio-signal monitoring and therapeutic applications

Kim,

et al. 2024

Soft Sci

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Short‐Peptide‐Induced Diffusion‐limited Plasmonic Aggregation with Broad Spectral Tunability for Wearable Ophthalmic Devices in Color Vision Deficiency Correction

Ran,

Chen,

et al. 2024

Adv Funct Materials

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Smart wearable ophthalmic devices such as contact lenses have gained widespread interest owing to their compactness, portability, and versatility and have emerged as the most promising, non‐invasive, wearable devices for the treatment and diagnosis of a variety of ocular diseases. While contact lenses for the treatment of congenital eye diseases such as color vision deficiency (CVD) are reported, they show limited spectral adjustment range and the unavailability of blocking harmful light such as high‐energy blue light (HEBL). In this study, silver nanoparticle (AgNP) based multifunctional contact lenses that can correct various types of CVDs and filter out harmful light are developed. AgNPs are controllably assembled via short‐peptide‐induced diffusion‐limited aggregation and then integrated into the contact lenses. By varying the sequence and concentration of the peptides, the extinction value of the nanoparticles can be broadly tuned in the 400–600 nm range. The multifunctional contact lenses thus show wide spectral tunability and are capable of efficiently correcting multiple CVDs and blocking HEBL. The contact lenses are found to have excellent biocompatibility with cell and animal tests. In conclusion, the multifunctional contact lenses provide a candidate for the correction of CVD and protection against HEBL, and pave the way for personalized wearable ophthalmic devices.

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Wearable Electrochemical Biosensors for Advanced Healthcare Monitoring

Duan,

Peng,

et al. 2024

Advanced Science

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Recent advancements in wearable electrochemical biosensors have opened new avenues for on‐body and continuous detection of biomarkers, enabling personalized, real‐time, and preventive healthcare. While glucose monitoring has set a precedent for wearable biosensors, the field is rapidly expanding to include a wider range of analytes crucial for disease diagnosis, treatment, and management. In this review, recent key innovations are examined in the design and manufacturing underpinning these biosensing platforms including biorecognition elements, signal transduction methods, electrode and substrate materials, and fabrication techniques. The applications of these biosensors are then highlighted in detecting a variety of biochemical markers, such as small molecules, hormones, drugs, and macromolecules, in biofluids including interstitial fluid, sweat, wound exudate, saliva, and tears. Additionally, the review also covers recent advances in wearable electrochemical biosensing platforms, such as multi‐sensory integration, closed‐loop control, and power supply. Furthermore, the challenges associated with critical issues are discussed, such as biocompatibility, biofouling, and sensor degradation, and the opportunities in materials science, nanotechnology, and artificial intelligence to overcome these limitations.

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Smart Contact Lenses for Healthcare Monitoring and Therapy

Cited by 12 publications

References 183 publications

Body-attachable multifunctional electronic skins for bio-signal monitoring and therapeutic applications

Body-attachable multifunctional electronic skins for bio-signal monitoring and therapeutic applications

Short‐Peptide‐Induced Diffusion‐limited Plasmonic Aggregation with Broad Spectral Tunability for Wearable Ophthalmic Devices in Color Vision Deficiency Correction

Wearable Electrochemical Biosensors for Advanced Healthcare Monitoring

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