Smart Design of Rapid Crystallizing and Nonleaching Antibacterial Poly(lactide) Nanocomposites by Sustainable Aminolysis Grafting and in Situ Interfacial Stereocomplexation

Abstract

Sustainable antibacterial poly­(lactide) (PLA) nanocomposites have attracted plenty of attention due to their potential application in biomedical and packaging fields. However, the preparation of nonleaching antibacterial PLA nanocomposites with high crystallinity is still a challenge due to their poor compatibility and the low crystallization rate of PLA. An effective and facile way by compounding poly­(d-lactide) (PDLA) with poly­(l-lactide) (PLLA)-grafted ZnO that was synthesized via in situ aminolysis reaction at the surface of ZnO was designed to simultaneously overcome these limitations. During solution mixing, the PDLA matrix and the grafted PLLA chains tend to orient side by side at the PDLA/ZnO interface and finally cocrystallize into stereocomplex (sc) crystallites. The interfacial stereocomplexation not only serves as a nucleator to increase the crystallization rate of the matrix but also effectively prevents ZnO from leaching out of the polymer matrix. Meanwhile, the nanocomposites have excellent biocompatibility. Therefore, it may provide an effective route to prepare advanced PLA-based materials with a fast crystallization rate, excellent biocompatibility, and nonleaching antibacterial property in this work, thus broadening the application range of PLA in biomedical applications.

Bicomponent PLA Nanofiber Nonwovens as Highly Efficient Filtration Media for Particulate Pollutants and Pathogens

“…It was seen from Figure 3b that the absorbance peak curves of the five samples varied from 650 to 1000 cm −1 . Moreover, another absorbance peak up-shifted from 868 to 872 cm −1 , denoting the variation of the C-COO bond, which further illustrated the interaction of the methyl group and carbonyl group to form the hydrogen bond between adjacent PLLA and PDLA molecular chains, driving the formation of SC-PLA [36]. In particular, a significantly new absorbance peak of the side-by-side bicomponent fiber appeared at 908 cm −1 , demonstrating a new characteristic peak of the stereo-complex crystal with 3 1 molecular helical conformation [37].…”

“…thyl group and carbonyl group to form the hydrogen bond between adjacent PLLA and PDLA molecular chains, driving the formation of SC-PLA [36]. In particular, a significantly new absorbance peak of the side-by-side bicomponent fiber appeared at 908 cm −1 , demonstrating a new characteristic peak of the stereo-complex crystal with 31 molecular helical conformation [37].…”

Extensional Stress-Induced Orientation and Crystallization can Regulate the Balance of Toughness and Stiffness of Polylactide Films: Interplay of Oriented Amorphous Chains and Crystallites

“…As a typical semi-crystalline polymer with a low crystallization rate and rigid chains, 30 there is ample space for tailoring the amorphous structure and the crystal structure simultaneously in PLA. In the present case, we utilize various extensional stress on PLA films for the two following objectives.…”

Nonleaching antimicrobial poly(vinyl alcohol)/polyhexamethylene guanidine hydrochloride hydrogels reinforced by hydrogen bond

“…Due to a potential concentration dependent toxicity, the concentration of antimicrobial agents applied in biomedical field must be kept as low as possible 26‐28 . Therefore, the development of hydrogel with highly effective antimicrobial property appeared to be necessary; meanwhile, the leaching effect of the incorporated antimicrobial agent had to be well controlled 29,30 …”

“…[26][27][28] Therefore, the development of hydrogel with highly effective antimicrobial property appeared to be necessary; meanwhile, the leaching effect of the incorporated antimicrobial agent had to be well controlled. 29,30 The aim of this research was to develop a nonleaching and highefficiency antimicrobial hydrogel using a simple and green route. Polyhexamethylene guanidine hydrochloride (PHMG) is water soluble, broad-spectrum antimicrobial, and widely used.…”