Smart DNA Hydrogel Integrated Nanochannels with High Ion Flux and Adjustable Selective Ionic Transport

Wu, Yafeng; Wang, Dianyu; Willner, Itamar; Tian, Ye; Jiang, Lei

doi:10.1002/ange.201803222

Cited by 27 publications

(13 citation statements)

References 28 publications

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“…G4-based hydrogels can be reversibly switched between less stiff and stiff networks upon treatment with potassium or crown ethers. 286 This example illustrates how quadruplex formation can affect the properties of hydrogels, but the inverse approach is possible as well: hydrogels can affect the properties of quadruplexes. Hasuike et al took advantage of the space inside thermoresponsive poly(N-isopropylacrylamide) gels to control the stability of G-quadruplex reversibly via variations in temperature (25−45 °C).…”

Section: Hydrogelsmentioning

confidence: 99%

DNA Quadruple Helices in Nanotechnology

2019

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DNA has played an early and powerful role in the development of bottomup nanotechnologies, not least because of DNA's precise, predictable, and controllable properties of assembly on the nanometer scale. Watson−Crick complementarity has been used to build complex 2D and 3D architectures and design a number of nanometer-scale systems for molecular computing, transport, motors, and biosensing applications. Most of such devices are built with classical B-DNA helices and involve classical A-T/U and G-C base pairs. However, in addition to the above components underlying the iconic double helix, a number of alternative pairing schemes of nucleobases are known. This review focuses on two of these noncanonical classes of DNA helices: G-quadruplexes and the imotif. The unique properties of these two classes of DNA helix have been utilized toward some remarkable constructions and applications: G-wires; nanostructures such as DNA origami; reconfigurable structures and nanodevices; the formation and utilization of hemin-utilizing DNAzymes, capable of generating varied outputs from biosensing nanostructures; composite nanostructures made up of DNA as well as inorganic materials; and the construction of nanocarriers that show promise for the therapeutics of diseases.

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Section: Hydrogelsmentioning

confidence: 99%

DNA Quadruple Helices in Nanotechnology

2019

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“…16,18a In addition, by the cooperative cross-linking of the polymer chains through permanent duplex nucleic acids and stimuliresponsive cross-linking units, stimuli-responsive hydrogels revealing controlled and switchable stiffness functions were prepared. Different applications of DNA-based stimuliresponsive hydrogels were discussed, including their use as shape-memory 22,34 and self-healing materials, 35 in controlled drug release, 36 as selective membranes for ion-transport, 37 and as mechanical devices. 38 In all of these systems, the stimuliresponsive hydrogel matrices include duplex nucleic acids as permanent linkers and co-participating stimuli-responsive switchable nucleic acids or supramolecular complexes as temporary linkers.…”

Section: ■ Introductionmentioning

confidence: 99%

Multi-triggered Supramolecular DNA/Bipyridinium Dithienylethene Hydrogels Driven by Light, Redox, and Chemical Stimuli for Shape-Memory and Self-Healing Applications

et al. 2018

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Multi-triggered DNA/bipyridinium dithienylethene (DTE) hybrid carboxymethyl cellulose (CMC)-based hydrogels are introduced. DTE exhibits cyclic and reversible photoisomerization properties, switching between the closed state (DTE c ), the electron acceptor, and the open isomer (DTE o ) that lacks electron acceptor properties. One system introduces a dual stimuli-responsive hydrogel containing CMC chains modified with electron donor dopamine sites and self-complementary nucleic acids. In the presence of DTE c and the CMC scaffold, a stiff hydrogel is formed, cooperatively stabilized by dopamine/DTE c donor−acceptor interactions and by duplex nucleic acids. The cyclic and reversible formation and dissociation of the supramolecular donor−acceptor interactions, through light-induced photoisomerization of DTE, or via oxidation and subsequent reduction of the dopamine sites, leads to hydrogels of switchable stiffness. Another system introduces a stimuli-responsive hydrogel triggered by one of three alternative signals. The stiff, multi-triggered hydrogel consists of CMC chains cross-linked by dopamine/DTE c donor−acceptor interactions, and by supramolecular K + -stabilized G-quadruplexes. The G-quadruplexes are reversibly separated in the presence of 18-crown-6 ether and reformed upon the addition of K + . The stiff hydrogel undergoes reversible transitions between highstiffness and low-stiffness states triggered by light, redox agents, or K + /crown ether. The hybrid donor−acceptor/G-quadruplex cross-linked hydrogel shows shape-memory and self-healing features. By using three different triggers and two alternative memory-codes, e.g., the dopamine/DTE c or the K + -stabilized G-quadruplexes, the guided shape-memory function of the hydrogel matrices is demonstrated.

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“…The negatively charged membrane contains a spongy porous supporting layer and a dense skin layer, which is rich in parallel continuous nanochannels. The nanochannels dominate ion-selective transport by facilitating transport of cations and rejecting anions [ 28 , 29 ]. As a result, the output power density of the membrane-based device reaches the commercialization benchmark of 5 W/m 2 .…”

Section: Introductionmentioning

confidence: 99%

Robust sulfonated poly (ether ether ketone) nanochannels for high-performance osmotic energy conversion

Zhao

Wang

Kong

et al. 2020

National Science Review

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The membrane-based reverse electrodialysis (RED) technique has a fundamental role in harvesting clean and sustainable osmotic energy existing in the salinity gradient. However, the current designs of membranes cannot cope with the high output power density and robustness. Here, we construct a sulfonated poly (ether ether ketone) (SPEEK) nanochannel membrane with numerous nanochannels for a membrane-based osmotic power generator. The parallel nanochannels with high space charges show excellent cation-selectivity, which could further be improved by adjusting the length and charge density of nanochannels. Based on numerical simulation, the system with space charge shows better conductivity and selectivity than those of a surface-charged nanochannel. The output power density of our proposed membrane-based device reaches up to 5.8 W/m2 by mixing artificial seawater and river water. Additionally, the SPEEK membranes exhibit good mechanical properties, endowing the possibility of creating a high-endurance scale-up membrane-based generator system. We believe that this work provides useful insights into material design and fluid transport for the power generator in osmotic energy conversion.

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Smart DNA Hydrogel Integrated Nanochannels with High Ion Flux and Adjustable Selective Ionic Transport

Cited by 27 publications

References 28 publications

DNA Quadruple Helices in Nanotechnology

DNA Quadruple Helices in Nanotechnology

Multi-triggered Supramolecular DNA/Bipyridinium Dithienylethene Hydrogels Driven by Light, Redox, and Chemical Stimuli for Shape-Memory and Self-Healing Applications

Robust sulfonated poly (ether ether ketone) nanochannels for high-performance osmotic energy conversion

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